Evaluation of the genotoxic spectrum of cisplatin for Candida albicans.

Abstract

The platinum co-ordination complex cisplatin [cis-diamminedichloroplatinum (II)] is a highly effective anticancer drug whose activity derives from its ability to form adducts crosslinking neighbouring purine bases in DNA. Under in vitro conditions, cisplatin induced cellular inactivation, forward and reverse mutations, reciprocal and nonreciprocal mitotic… (More)

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@article{Sarachek1992EvaluationOT, title={Evaluation of the genotoxic spectrum of cisplatin for Candida albicans.}, author={Alvin Sarachek and Lauren A. Henderson and William Wilkens}, journal={Microbios}, year={1992}, volume={72 292-293}, pages={183-201} }