Evaluation of the genotoxic activity of 2-nitroanthrafurans.

@article{Quillardet1988EvaluationOT,
  title={Evaluation of the genotoxic activity of 2-nitroanthrafurans.},
  author={P. Quillardet and C. Bilger and P. Demerseman and R. Royer and M. Hofnung},
  journal={Mutation research},
  year={1988},
  volume={204 2},
  pages={
          141-7
        }
}
We measured the genotoxic activities in two bacterial tests, the Salmonella/histidine assay (a reverse mutation assay) and the SOS chromotest (an assay for SOS induction in E. coli), of three 2-nitroanthrafurans: 2-nitroanthra[1,2-b]furan (R-7688), the isomeric compound 2-nitroanthra[2,1-b]furan (R-7686) and its 8-methoxylated derivative (R-7707). Their genotoxic activities were compared to that of 7-methoxy-2-nitronaphtho[2,1-b]furan (R-7000) which has been studied in previous works (Arnaise… Expand
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References

SHOWING 1-10 OF 14 REFERENCES
Genotoxic activity of two furan analogues of benzo[a]pyrene and their 2-nitro derivatives.
TLDR
The responses to the two pyrenofurans were increased in the presence of an "activating mixture" but were still lower than that to benzo[a]pyrene and pyreno[1,2-b]furan (R7490), and compounds with the oxygen heteroatom within the "bay region" gave lower responses than their isomeric furan analogues outside the "Bay region". Expand
Genotoxic activities of 2-nitronaphthofurans and related molecules.
The genotoxic activities of 63, 2-nitronaphthofurans and related molecules were examined using two bacterial short-term tests, the Salmonella mammalian microsome assay test or Mutatest, a mutagenesisExpand
Mutagenic activity of benzofurans and naphthofurans in the Salmonella/microsome assay: 2-nitro-7-methoxy-naphtho[2,1-b]furan (R7000), a new highly potent mutagenic agent.
TLDR
One of the compounds tested, 2-nitro-7-methoxynaphtho[2,1-b]furan (R7000), may be the most potent mutagen examined so far in the Salmonella/microsome assay and depends notably on the nature and the position of the other substituents in the molecule. Expand
Relationship between the chemical structure and the mutagenic and carcinogenic potentials of five naphthofurans.
TLDR
The positive results obtained in the cell transformation assays and in the short-term skin tests indicate that Compounds A, B, and C are probably carcinogenic, and further in vivo studies should be accomplished before using the 2-nitronaphthofuran derivatives in human and animal treatments. Expand
Genetic toxicology studies with 2-nitrobenzofurans and 2-nitronaphthofurans.
TLDR
A correlation is observed between the mutagenic potency assayed in the Mutatest and the phage-inducing potency assays in the Inductest, and the relevance of complementary tests on uvr + Salmonella strains and the Spermatest are briefly discussed. Expand
SOS chromotest, a direct assay of induction of an SOS function in Escherichia coli K-12 to measure genotoxicity.
TLDR
The results suggest that mutagenic potency measured in the mutatest reflects the level of induction of an SOS function and that most genotoxins are inducers of the SOS response in bacteria. Expand
Synthesis, spectral analysis, and mutagenicity of 1-, 3-, and 6-nitrobenzo[a]pyrene.
TLDR
Comparison of the spectral data of these compounds with those obtained from direct nitration of benzo[a]pyrene confirmed that 1- and 3-nitrobenzo[ a]pyrenes are indeed the minor products of the latter reaction, and verifies that the minor nitrated products of benzos[a ]pyrene formed in model air atmospheres. Expand
Induction of sarcomas in rats by subcutaneous injection of 7-methoxy-2-nitro-naphtho[2,1-b]furan (R 7000).
TLDR
The high carcinogenicity of R 7000 in vivo is analogous to that of methylcholanthrene, and the exact mechanism of action of 2-nitro-naphthofurans as carcinogens remains to be explained. Expand
The SOS Chromotest, a colorimetric bacterial assay for genotoxins: procedures.
TLDR
A simple spot-test procedure as well as a new standard procedure which incorporate recent technical improvements aimed at simplifying the assay further are reported. Expand
Revised methods for the Salmonella mutagenicity test.
TLDR
Two new tester strains, a frameshift strain and a strain carrying an ochre mutation on a multicopy plasmid (TA102), are added to the standard tester set and two substitutions are made in diagnostic mutagens to eliminate MNNG and 9-aminoacridine. Expand
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