Evaluation of the general suitability of the rat for the micronucleus assay: the effect of cyclophosphamide in 14 strains.

@article{Hamada2001EvaluationOT,
  title={Evaluation of the general suitability of the rat for the micronucleus assay: the effect of cyclophosphamide in 14 strains.},
  author={Shuichi Hamada and Kanji Yamasaki and Shuhei Nakanishi and Takashi Omori and Tadao Serikawa and Makoto Hayashi},
  journal={Mutation research},
  year={2001},
  volume={495 1-2},
  pages={127-34}
}
To evaluate the general suitability of the rat for the micronucleus assay, we conducted the assay in males of 14 different strains, 13 inbred (ACI, BN, BUF, COP, DRH, F344, IS, LEW, RCS, SHR, WAG, WKYO, WTC) and 1 outbred (SD), using cyclophosphamide as the test chemical. Cyclophosphamide at 0 (vehicle), 5, 10, or 20mg/kg per day was administered orally twice, 24h apart, to five rats per dosage group. Bone marrow and peripheral blood were collected 24h after the second treatment. All 14 strains… CONTINUE READING
7 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…