Evaluation of the factors influencing stomach-specific delivery of antibacterial agents for Helicobacter pylori infection.

@article{Shah1999EvaluationOT,
  title={Evaluation of the factors influencing stomach-specific delivery of antibacterial agents for Helicobacter pylori infection.},
  author={Sima D Shah and Roula B Qaqish and Vishal Patel and Mansoor M Amiji},
  journal={The Journal of pharmacy and pharmacology},
  year={1999},
  volume={51 6},
  pages={667-72}
}
Because Helicobacter pylori infection is localized in the gastric mucus layer and at the mucus layer-epithelial cell interface, we have developed amoxycillin- and metronidazole-containing chitosan microspheres for stomach-specific drug delivery. Drug-loaded porous chitosan microspheres were prepared by simultaneous crosslinking and precipitation with sodium tripolyphosphate. The release of antibacterial agents into simulated gastric fluid (SGF, pH 1.2), and the stability and permeability… CONTINUE READING
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