Evaluation of the effect of food and gastric pH on the single-dose pharmacokinetics of cabozantinib in healthy adult subjects.

@article{Nguyen2015EvaluationOT,
  title={Evaluation of the effect of food and gastric pH on the single-dose pharmacokinetics of cabozantinib in healthy adult subjects.},
  author={Linh Thi Thao Nguyen and Jaymes S Holland and Richard D. Mamelok and M. Laberge and Julie Grenier and Dennis Swearingen and Danielle Armas and Steven A Lacy},
  journal={Journal of clinical pharmacology},
  year={2015},
  volume={55 11},
  pages={1293-302}
}
Cabozantinib is a small molecule tyrosine kinase inhibitor that has been approved for the treatment of patients with progressive, metastatic medullary thyroid cancer. Cabozantinib exhibits a pH-dependent solubility profile in vitro. Two phase 1 clinical pharmacology studies were conducted in healthy subjects to evaluate whether factors that may affect… CONTINUE READING