Evaluation of the effect of different fatty acids on the percutaneous absorption of metaproterenol sulfate.

  title={Evaluation of the effect of different fatty acids on the percutaneous absorption of metaproterenol sulfate.},
  author={Benjamin M. P. Elyan and Madiha B. Sidhom and Fotios M. Plakogiannis},
  journal={Journal of pharmaceutical sciences},
  volume={85 1},
The in vitro permeation rates of metaproterenol sulfate (MPS) across hairless mouse skin and TESTSKIN living skin equivalent were very low unless skin permeation enhancers were included in the vehicle. An optimum balance should be established between the chain length of the fatty acid and its molar ratio to MPS in order to enhance its penetration through the skin. Thus, the best flux values were shown by capric acid: MPS, 3:1 molar ratio, and lauric acid:MPS, 1:1 and 2:1 molar ratio, while… Expand
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  • S. Santoyo, P. Ygartua
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2000
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S.L. Bennett* and B.W. Barry, Postgraduate School of Studies i n Pharmacy, University of Bradford, Bradford, West Yorkshire, BD7 IDP, U.K. *Present address: Glaxo Group Research Ltd., Greenford,Expand
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