Evaluation of the effect of cobicistat on the in vitro renal transport and cytotoxicity potential of tenofovir.

@article{Stray2013EvaluationOT,
  title={Evaluation of the effect of cobicistat on the in vitro renal transport and cytotoxicity potential of tenofovir.},
  author={Kirsten M. Stray and Rujuta A. Bam and Gabriel Birku{\vs} and Jia Hao and Eve-Irene Lepist and Stephen R. Yant and Adrian S Ray and Tom{\'a}{\vs} Cihl{\'a}ř},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 10},
  pages={4982-9}
}
A once-daily single-tablet antiretroviral regimen containing tenofovir (TFV) disoproxil fumarate, emtricitabine (FTC), elvitegravir (EVG), and cobicistat (COBI) is an approved combination for the treatment of patients infected with HIV. COBI and TFV have been reported to interact with distinct transporters in renal proximal tubules; while TFV is renally eliminated by a combination of glomerular filtration and tubular secretion via anion transporters OAT1, OAT3, and MRP4, COBI inhibits renal… CONTINUE READING

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