Evaluation of the effect of cagPAI genes of Helicobacter pylori on AGS epithelial cell morphology and IL-8 secretion

@article{Salih2013EvaluationOT,
  title={Evaluation of the effect of cagPAI genes of Helicobacter pylori on AGS epithelial cell morphology and IL-8 secretion},
  author={Barik A. Salih and Ahmet Guner and Ahu Karademir and Merve Uslu and Mehmet Akif Ovali and Duygu Yazici and Bora Kazim Bolek and Soykan Ar{\^i}kan},
  journal={Antonie van Leeuwenhoek},
  year={2013},
  volume={105},
  pages={179-189}
}
Helicobacter pylori cagPAI genes play an important role in pathogenesis, however little is known about their functions in isolates from Turkish patients. We aimed to evaluate the intactness and the effect of the cagPAI genes (cagT, cagM, cagE, cagA) and cagA EPIYA motifs on the AGS morphological changes and IL-8 induction. Of 53 patients 38 were found infected with H. pylori. PCR amplification of the cagPAI genes showed 42.1 % intact, 39.5 % partially deleted and 18.4 % with complete deletions… CONTINUE READING
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