Evaluation of the dose response and in utero exposure to saccharin in the rat.

Abstract

A two-generation bioassay on sodium saccharin (NaS), involving 2500 second-generation male rats, was designed to determine the dose response for urinary bladder tumours in male rats and to evaluate other changes possibly related to the occurrence of the tumours. Six treatment groups (125-700 rats/group) were fed dietary levels of NaS ranging from 1.0 to 7.5… (More)

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@article{Schnig1985EvaluationOT, title={Evaluation of the dose response and in utero exposure to saccharin in the rat.}, author={Gisela Sch{\"o}nig and E I Goldenthal and Rachel Geil and Christopher Frith and Wiltrud Richter and F W Carlborg}, journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association}, year={1985}, volume={23 4-5}, pages={475-90} }