Evaluation of the diagnostic efficiency of a recombinant antigen modeling the immunogenic epitope V3 of the envelope protein gp120 for immunoenzyme detection of antibodies to HIV-1

Abstract

It is known that the third hypervariable domain V3 of the HIV-1 glycoprotein gp120 plays a major role in the interaction with neutralizing antibodies and is one of the significant serologic markers in the diagnosis of HIV infection. Neutralization of the antibodies is ensured by the conserved tripeptide GPG, a structural component of the V3 loop. The… (More)
DOI: 10.3103/S0891416807030068

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