Evaluation of the developmental toxicity of lenalidomide in rabbits.


BACKGROUND Lenalidomide, a thalidomide analog, is indicated for treatment of patients with deletion-5q myelodysplastic syndromes or multiple myeloma. NZW rabbits were used because of sensitivity to thalidomide's teratogenicity. METHODS Range-finding and pulse-dosing studies preceded a full developmental toxicity study in New Zealand white (NZW) rabbits… (More)