Evaluation of the developmental toxicity of annatto in the rat.

@article{Paumgartten2002EvaluationOT,
  title={Evaluation of the developmental toxicity of annatto in the rat.},
  author={Francisco J R Paumgartten and Rosangela Ribeiro De-Carvalho and Izeneide Barros de Ara{\'u}jo and Francisco Mar{\'i}a Pinto and Olga Borges and CarminoA. Souza and Sergio Noboru Kuriyama},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2002},
  volume={40 11},
  pages={
          1595-601
        }
}
Annatto, a dye extracted from Bixa orellana seeds, is used as a color additive in butter, cheese and in a variety of other foods as well as in drugs and cosmetics. Toxicological data on annatto and on its main carotenoid pigment bixin are still scarce. In this study we evaluated the developmental toxicity of annatto (28% of bixin). Annatto (0, 31.2, 62.5, 125, 250 and 500 mg/kg body weight/day) was given by gavage to Wistar rats on days 6-15 of pregnancy. Ceasarean sections were performed on… CONTINUE READING
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