Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischemia-injured jejunal mucosa in horses.

@article{Marshall2011EvaluationOT,
  title={Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischemia-injured jejunal mucosa in horses.},
  author={John F Marshall and Adria S. Bhatnagar and Susan G. Bowman and Christina Marie Howard and Natalie N. Morris and Dinah A. Skorich and Caitlyn D Redding and Anthony T. Blikslager},
  journal={American journal of veterinary research},
  year={2011},
  volume={72 2},
  pages={
          226-32
        }
}
OBJECTIVE To determine the cyclooxygenase (COX) selectivity of robenacoxib and its effect on recovery of jejunal mucosa following ischemic injury in horses. ANIMALS 12 healthy horses. PROCEDURES Half the maximal inhibition (EC₅₀) of robenacoxib for COX-1 and COX-2 activity was established in bloods samples from 6 horses via measurement of thromboxane B₂ (TXB₂) and prostaglandin E₂ concentrations, respectively; COX selectivity was subsequently calculated. Six other horses were anesthetized… 
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