Evaluation of the cost-utility of insulin degludec vs insulin glargine in Sweden
@article{Ericsson2013EvaluationOT, title={Evaluation of the cost-utility of insulin degludec vs insulin glargine in Sweden}, author={{\AA}sa Ericsson and R. F. Pollock and Barnaby Hunt and William J. Valentine}, journal={Journal of Medical Economics}, year={2013}, volume={16}, pages={1442 - 1452} }
Abstract Objective: To evaluate the annual cost-utility of insulin degludec compared with glargine in patients with: type 1 diabetes (T1D), type 2 diabetes receiving basal-only therapy (T2D-BOT), and type 2 diabetes receiving basal-bolus therapy (T2B-BB) in Sweden. Methods: A cost-utility model was programmed in Microsoft Excel to evaluate clinical and economic outcomes. The clinical trials were designed as treat-to-target, with insulin doses adjusted in order to achieve similar glycemic…
28 Citations
Cost-effectiveness of Insulin Degludec Versus Insulin Glargine in Insulin-naive Chinese Patients With Type 2 Diabetes.
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Under routine care, switching to degludec is dominant, compared with continuing previous basal insulin, in Italian patients with T1D or T2D, meaning that patient health was improved in terms of QALYs with lower healthcare costs.
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IDeg is a cost-effective alternative to IGlar U100 for patients with diabetes in the UK, and it is likely to be cost- effective versus two new-to-market basal insulin analogues, with incremental cost-effectiveness ratios below the accepted threshold.
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Over a 1-year time horizon, insulin degludec resulted in cost savings relative to insulin glargine in T1D and T2DBOT cohorts, while being cost-effective in T2 DBB.
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The authors' long-term modeling analysis suggested that degludec was cost effective (from the perspective of NHS England) versus glargine U100 in basal–bolus regimens for patients with T2D at high CV risk.
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Using IDeg instead of IGlar at list price could result in a modest increase in costs when considering insulin and hypoglycemia costs alone, but modest incremental rebates with IDeg would result in cost neutrality relative to I Glar.
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Degludec is a cost-effective alternative to biosimilar glargine U100 for patients with T1DM and T2DM in Bulgaria and could be of particular benefit to those patients suffering recurrent hypoglycaemia and those who require additional flexibility in the dosing of insulin.
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Insulin degludec was projected to be cost-effective or dominant versus other basal insulins for the treatment of T1D and T2D in Sweden and was associated with improved quality-adjusted life expectancy and lower incidences of diabetes-related complications.
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Degludec is a cost-effective alternative to glargine U100 for patients with T1DM and T2DM in Serbia and may particularly benefit those suffering from hypoglycaemia or where the patient would benefit from the option of flexible dosing.
References
SHOWING 1-10 OF 37 REFERENCES
Cost-effectiveness of switching patients with type 2 diabetes from insulin glargine to insulin detemir in Chinese setting: a health economic model based on the PREDICTIVE study.
- MedicineValue in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
- 2012
Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes.
- MedicineThe New England journal of medicine
- 2007
The addition of biphasic or prandial insulin aspart reduced levels more than the addition of basal insulin detemir but was associated with greater risks of hypoglycemia and weight gain.
Insulin degludec as an ultralong-acting basal insulin once a day: a systematic review
- MedicineDiabetes, metabolic syndrome and obesity : targets and therapy
- 2012
There appear to be no reported differences between IDeg and IGlar, detemir, or BIAsp 30 in the reduction of the primary efficacy end-points of HbA1c and mean fasting plasma glucose (FPG) concentrations.
Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus.
- MedicineThe Cochrane database of systematic reviews
- 2007
The analysis suggests, if at all only a minor clinical benefit of treatment with long-acting insulin analogues for patients with diabetes mellitus type 2 treated with "basal" insulin regarding symptomatic nocturnal hypoglycaemia was statistically significantly lower in patients treated with either insulin glargine or detemir.
Cost-effectiveness of sensor-augmented pump therapy in adults with type 1 diabetes in the United States.
- Medicine, Political ScienceValue in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
- 2012
Insulin Degludec Once-Daily in Type 2 Diabetes: Simple or Step-Wise Titration (BEGIN: Once Simple Use)
- MedicineAdvances in Therapy
- 2013
Insulin degludec was effective and well tolerated using either the Simple or Step-wise titration algorithm, and may enable patient empowerment through self-titration, improved convenience, and reduced costs.
Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: a pre-planned meta-analysis of phase 3 trials
- MedicineDiabetes, obesity & metabolism
- 2013
This pre‐planned meta‐analysis aimed to demonstrate the superiority of IDeg over insulin glargine (IGlar) in terms of fewer hypoglycaemic episodes at equivalent HbA1c in type 2 and type 1 diabetes mellitus (T2DM/T1DM).
Cost of hypoglycemia in patients with Type 2 diabetes in Sweden.
- MedicineValue in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
- 2006
The results indicate that hypoglycemic events lead to substantial costs, but data are scarce and more studies are needed to better understand the cost and consequences of hypoglycemia.
Strategies to Limit the Effect of Hypoglycemia on Diabetes Control: Identifying and Reducing the Risks
- MedicineClinical Diabetes
- 2012
The risk of hypoglycemia should not be used as an excuse for less-than-optimal glucose control and improved glycemic control prevents or delays microvascular complications and may also reduce macrovascular events.