Evaluation of the bone healing process in an experimental tibial bone defect model in ovariectomized rats.

@article{Kido2014EvaluationOT,
  title={Evaluation of the bone healing process in an experimental tibial bone defect model in ovariectomized rats.},
  author={Hueliton Wilian Kido and Paulo S{\'e}rgio Bossini and Carla Roberta Tim and Nivaldo Antonio Parizotto and Anderson Ferreira da Cunha and Iran Malavazi and Ana Cl{\'a}udia Muniz Renn{\'o}},
  journal={Aging clinical and experimental research},
  year={2014},
  volume={26 5},
  pages={473-81}
}
The aim of this study was to evaluate the influence of postmenopausal bone loss (induced by ovariectomy) in the process of bone healing in a tibial bone defect model in rats by means of histological evaluation of bone defects and the analysis of the expression of genes and proteins involved in bone consolidation. Twenty female Wistar rats (12 weeks old, weighing ±250 g) were randomly divided into two groups: control group (CG) and ovariectomized group (OG). Rats of OG were submitted to… CONTINUE READING

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