Evaluation of the bioactive properties of avenanthramide analogs produced in recombinant yeast.

@article{Moglia2015EvaluationOT,
  title={Evaluation of the bioactive properties of avenanthramide analogs produced in recombinant yeast.},
  author={Andrea Moglia and Luca Goitre and Silvia Gianoglio and Eva Baldini and Eliana Trapani and Andrea Genre and Antonella Scattina and Giancarlo Dondo and Lorenza Trabalzini and Jules Beekwilder and Saverio Francesco Retta},
  journal={BioFactors},
  year={2015},
  volume={41 1},
  pages={
          15-27
        }
}
Saccharomyces cerevisiae has been proven to be a valuable tool for the expression of plant metabolic pathways. By engineering a S. cerevisiae strain with two plant genes (4cl-2 from tobacco and hct from globe artichoke) we previously set up a system for the production of two novel phenolic compounds, N-(E)-p-coumaroyl-3-hydroxyanthranilic acid (Yeast avenanthramide I, Yav I) and N-(E)-caffeoyl-3-hydroxyanthranilic acid (Yeast avenanthramide II, Yav II). These compounds have a structural… CONTINUE READING
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