Evaluation of the binding of the radiolabeled antidepressant drug, 18F-fluoxetine in the rodent brain: an in vitro and in vivo study.

@article{Mukherjee1998EvaluationOT,
  title={Evaluation of the binding of the radiolabeled antidepressant drug, 18F-fluoxetine in the rodent brain: an in vitro and in vivo study.},
  author={Jogeshwar Mukherjee and Malay Kanti Das and Zheng Yu Yang and Rebecca Lew},
  journal={Nuclear medicine and biology},
  year={1998},
  volume={25 7},
  pages={605-10}
}
We have developed 18F-fluoxetine as a radiotracer analog of the antidepressant drug fluoxetine (Prozac). In vitro saturation experiments of 18F-fluoxetine were carried out on rat midbrain tissue and citalopram was used for measuring nonspecific binding. A saturation curve for the binding of 18F-fluoxetine was not obtained. Even when fluoxetine (10 microM) was used for measurements of nonspecific binding, a saturation curve was difficult to obtain. Other compounds, such as deprenyl, clorgyline… CONTINUE READING
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