Evaluation of the basic functions of six calcium-dependent protein kinases in Toxoplasma gondii using CRISPR-Cas9 system

@article{Wang2015EvaluationOT,
  title={Evaluation of the basic functions of six calcium-dependent protein kinases in Toxoplasma gondii using CRISPR-Cas9 system},
  author={Jin-Lei Wang and Si-Yang Huang and Ting-Ting Li and Kai Chen and H. Ning and Xing-Quan Zhu},
  journal={Parasitology Research},
  year={2015},
  volume={115},
  pages={697-702}
}
Toxoplasma gondii, an important protozoan parasite, infects almost all warm-blooded animals and humans. Although treatments in T. gondii are limited by the lack of effective drugs, some calcium-dependent kinases were demonstrated as the promising drug targets to chemotherapy against T. gondii due to their essential roles in T. gondii and absence from their hosts. The objectives of the present study were to investigate the functions of six calcium-dependent protein kinases (CDPK4, CDPK4A, CDPK5… Expand
Functional Characterization of Two Thioredoxin Proteins of Toxoplasma gondii Using the CRISPR-Cas9 System
Calcium-dependent protein kinases are potential targets for Toxoplasma gondii vaccine
Characterization of Three Calcium-Dependent Protein Kinases of Cryptosporidium parvum
Effect of deletion of gra17 and gra23 genes on the growth, virulence, and immunogenicity of type II Toxoplasma gondii
The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design
...
1
2
3
...

References

SHOWING 1-10 OF 29 REFERENCES
A Forward Genetic Screen Reveals that Calcium-dependent Protein Kinase 3 Regulates Egress in Toxoplasma
Genome-wide expression patterns of calcium-dependent protein kinases in Toxoplasma gondii
TgCDPK3 Regulates Calcium-Dependent Egress of Toxoplasma gondii from Host Cells
Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9
CDPKs of Cryptosporidium parvum—stage-specific expression in vitro
Efficient Genome Engineering of Toxoplasma gondii Using CRISPR/Cas9
Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans.
Toxoplasma aldolase is required for metabolism but dispensable for host-cell invasion
  • B. Shen, L. Sibley
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2014
...
1
2
3
...