Evaluation of the antilipolytic action of clomiphene in vitro.

@article{Estler1976EvaluationOT,
  title={Evaluation of the antilipolytic action of clomiphene in vitro.},
  author={C. Estler and P. Mitznegg},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={1976},
  volume={8 2},
  pages={
          114-7
        }
}
  • C. Estler, P. Mitznegg
  • Published 1976
  • Biology, Medicine
  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Clomiphene (10(-3) - 10(-2) M) in a dose-dependent manner inhibited the lypolytic response of isolated rat epididymal adipose tissue and fat cells to epinephrine, ACTH, and dibutyryl-cyclic AMP. Furthermore, it reduced the non-hormonally stimulated activity of a crude preparation of lipase from epididymal adipose tissue. The accumulation of cyclic AMP produced by epinephrine in fat cells was not prevented by clomiphene at a concentration causing antilipolytic activity. It is concluded from… Expand
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