Evaluation of the antibacterial activity of contact lens solutions

  title={Evaluation of the antibacterial activity of contact lens solutions},
  author={R. J. Mcbride and M A Mackie},
  journal={Journal of Pharmacy and Pharmacology},
4 Citations
The chemical degradation of phenylmercuric nitrate by disodium edetate during heat sterilization at pH values commonly encountered in ophthalmic products
Application of high‐performance liquid chromatography and atomic absorption spectroscopy to autoclaved solutions containing PM nitrate and disodium edetate demonstrates that under the conditions of heat sterilization the phenylmercuric ion is degraded to mercuric ion and benzene to the extent of 15% at pH 8, 80%, at pH 7 and completely degraded at pH 5 and 6. Expand
Determination of lidocaine and active metabolites in blood serum by liquid chromatography with electrochemical detection.
The resulting assay was suitable for the routine quantitation of lidocaine and these metabolites in blood serum over the entire therapeutic range, 1-6 micrograms/ml. Expand
Contamination of Antiseptics and Use of Preservatives
Antiseptic substances such as benzalkonium chloride, chlorhexidine and organic mercurial compounds are also employed as antimicrobial preservatives in pharmaceutical preparations. Some of theseExpand
The antipseudomonal activity of contact lens solutions
  • R. Richards
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1975


Preservation of sodium bicarbonate eye lotion BPC against contamination with Pseudomonas aeruginosa.
It has been suggested that a sterilizing time of I hour or less is what should be expected of an antibacterial substance considered suitable for the preservation of ophthalmic solutions, and 2-phenylethanol (PEA) is a more effective preservative system for fluorescein sodium eye drops than the official BPC formulation, which is preserved with PMN alone. Expand
The preservation of ophthalmic solutions with antibacterial combinations
Phenylethanol‐antibacterial combinations were consistently effective in killing the inoculum within 15 min except for one formulation with chlorhexidine and physostigmine salicylate and formulations with PMN for which sterilization times ranged from 30 to 90 min. Expand
Survival of Pseudomonas aeruginosa in fluorescein solution. Preservative action of PMN and EDTA
Colony counts were made for a year on washed and unwashed cells of Ps. aeruginosa inoculated into fluorescein sodium solution, 2 percent in water (pH 8.6), into nutrient broth, into tris buffer (pHExpand
Antibacterial agents in Pseudomonas aeruginosa contaminated ophthalmic solutions.
In vivo rabbit corneal tests along with improved techniques of invitro testing indicate that bactericidal concentrations of preservatives are required for maximum safety in ophthalmic solutions. Expand