Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat.

@article{AbdelSalam2004EvaluationOT,
  title={Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat.},
  author={Omar M. E. Abdel-Salam and Ayman R. Baiuomy and Seham El-batran and Mahmoud. S. Arbid},
  journal={Pharmacological research},
  year={2004},
  volume={49 2},
  pages={
          133-42
        }
}
Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rats
TLDR
Data show that bilobalide is a potent anti-inflammatory and antihyperalgesic agent, the therapeutic effects of which are mediated in part through a central site of action, and may account for the therapeutic action of the whole extract G. biloba.
Central and Local Administration of Gingko Biloba Extract EGb 761® Inhibits Thermal Hyperalgesia and Inflammation in the Rat Carrageenan Model
TLDR
These studies show that EGb 761 acts both at the site of inflammation and centrally at the spinal cord level to inhibit inflammation and thermal hyperalgesia, and may be useful in the treatment of inflammatory pain.
Prophylactic Administration of Ginkgo biloba Leaf Extract (EGb 761) Inhibits Inflammation in Carrageenan Rat Paw Edema Model. J. Life Sci. Biomed. 8(2): 31-36; www.jlsb.science-line.com
TLDR
The acute toxicity tests result showed that the extract is safe at 5000mg/kg dose and the findings further justify the use of Ginkgo biloba leaf extract in both medical and ethnomedical practice and may be used in treatment of inflammation.
Inhibition of Carrageenan-Induced Acute Inflammation in Mice by Oral Administration of Anthocyanin Mixture from Wild Mulberry and Cyanidin-3-Glucoside
TLDR
It is suggested that anthocyanin-enriched fraction and the cyanidin-3-glucoside (C3G) present positive contributions as dietary supplements and minimize acute inflammation.
Protective Effect and Potential Mechanism of Ginkgo biloba Extract EGb 761 on STZ‐induced Neuropathic Pain in Rats
TLDR
EGb 761 attenuated STZ‐induced neuropathic pain behaviours by inhibiting oxidative and nitrosative stress and may constitute a new approach for treatment of painful diabetic neuropathy.
The Effects of Ginkgo Biloba Extract EGb 761 on Mechanical and Cold Allodynia in a Rat Model of Neuropathic Pain
TLDR
It is concluded that Ginkgo biloba extract, EGb 761, attenuates mechanical and cold allodynia in a rat model of neuropathic pain, and it may be useful for the management of Neuropathic pain.
Ginkgo biloba Extract Attenuates Hyperalgesia in a Rat Model of Vincristine-Induced Peripheral Neuropathy
TLDR
It is demonstrated that oral administration of GBE is associated with a dose-dependent antihyperalgesic effect on mechanical and cold stimuli in a rat model of vincristine-induced neuropathy.
The effects of Gingko biloba extract on acetic acid-induced colitis in rats.
TLDR
Gingko biloba did not significantly affect histopathological and oxidative stress parameters in experimental colitis and did not affect tissue and serum MDA levels.
Anti-inflammatory Effect of Jungcheonhwadamgangki-tang in Formalin-Injection Mouse Paw Chronic Inflammation Model
TLDR
It is concluded that Jungcheonhwadamgangki-tang have clear anti-inflammatory effect on the chronic inflammation induced by formalin-injection.
What is the possible therapeutic effect of Ginkgo biloba on gastric ulcer induced by ammonia in albino rats?
TLDR
After the administration of Ginkgo biloba, there was an improvement in gastric lesions, with a significant reduction of ulcer score, MPO, and IL-1β and a significant increase in GSH, mucus content, and gastric pH.
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