Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin‐induced pain and hyperalgesia

@article{Kalliomki2013EvaluationOT,
  title={Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin‐induced pain and hyperalgesia},
  author={Jarkko Kalliom{\"a}ki and Peter Annas and Karin Huizar and Cyril P. Clarke and Annika Zettergren and Rolf Karlsten and M{\"a}rta Segerdahl},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2013},
  volume={40}
}
The aim of the present study was to investigate the effects of AZD1940, a novel peripherally acting cannabinoid CB1/CB2 receptor agonist, on capsaicin‐induced pain and hyperalgesia, as well as on biomarkers of cannabinoid central nervous system (CNS) effects. The present study was a randomized, double‐blind, placebo‐controlled, four‐sequence, two‐period, cross‐over study in 44 male healthy volunteers aged 20–45 years. The effects of two single oral doses of AZD1940 (400 and 800 μg) were… 

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