Evaluation of the Xpert™ MRSA/SA Blood Culture assay for the detection of Staphylococcus aureus including strains with reduced vancomycin susceptibility from blood culture specimens.

@article{Kelley2011EvaluationOT,
  title={Evaluation of the Xpert™ MRSA/SA Blood Culture assay for the detection of Staphylococcus aureus including strains with reduced vancomycin susceptibility from blood culture specimens.},
  author={Peter G Kelley and Elizabeth A. Grabsch and Jenny Farrell and Shirley Y. Xie and Janet Montgomery and Barrie C Mayall and Benjamin P Howden},
  journal={Diagnostic microbiology and infectious disease},
  year={2011},
  volume={70 3},
  pages={404-7}
}
The Xpert MRSA/SA Blood Culture (BC) assay (Cepheid, Sunnyvale, CA) was prospectively compared to culture and found to have excellent specificity for both Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in BC specimens with a sensitivity of 75% (3/4) and 100% (17/17), respectively. Among 28 heterogeneous vancomycin-intermediate S. aureus (hVISA)/VISA spiked BCs, the assay correctly identified 84.6% VISA and 80% hVISA isolates as MRSA. 

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