Evaluation of the Stability of DNA i‐Motifs in the Nuclei of Living Mammalian Cells

C-rich DNA has the capacity to form a tetra-stranded structure known as an i-motif. The i-motifs within genomic DNA have been proposed to contribute to the regulation of DNA transcription. However, direct experimental evidence for the existence of these structures in vivo has been missing. Whether i-motif structures form in complex environment of living… CONTINUE READING