Evaluation of the Short-Term Treatment of Insomnia in Out-Patients with 15 Milligrams of Quazepam

@article{Mendels1983EvaluationOT,
  title={Evaluation of the Short-Term Treatment of Insomnia in Out-Patients with 15 Milligrams of Quazepam},
  author={Joseph Mendels and Stephen L. Stern},
  journal={Journal of International Medical Research},
  year={1983},
  volume={11},
  pages={155 - 161}
}
  • J. Mendels, S. Stern
  • Published 1 May 1983
  • Psychology, Medicine
  • Journal of International Medical Research
The short-term safety and hypnotic efficacy of 15 mg of quazepam was compared with that of placebo in a double-blind study in sixty out-patients with insomnia. All patients received placebo for 3 consecutive nights to establish a baseline; for the next 5 nights thirty patients received quazepam and thirty received placebo. The results indicated that quazepam was significantly more effective than placebo in terms of quantity and quality of sleep and that quazepam was effective on the first night… 

Figures and Tables from this paper

Quazepam. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in insomnia.
TLDR
Preliminary evidence suggests that quazepam 15 to 30 mg is as effective as flurAZepam and triazolam in usual therapeutic doses, and causes minimal rebound insomnia following its withdrawal, unlike rapidly eliminated benzodiazepines such as triazlam.
Quazepam: Hypnotic Efficacy and Side Effects
  • A. Kales
  • Medicine, Psychology
    Pharmacotherapy
  • 1990
TLDR
Quazepam is a benzodiazepine hypnotic that can be useful in the adjunctive pharmacologic treatment of insomnia and is more effective with short‐term use, and with continued use it maintains its efficacy in contrast to both of these drugs which show rapid development of tolerance.
Benzodiazepines and zolpidem for chronic insomnia: a meta-analysis of treatment efficacy.
TLDR
Benzodiazepines and zolpidem produced reliable improvements in commonly measured parameters of sleep in patients with chronic insomnia, and presented challenges for developing evidence-based guidelines for the use of hypnotics in the management of chronic insomnia.
Reintroduction of quazepam: an update on comparative hypnotic and adverse effects.
  • N. Moniri
  • Psychology, Biology
    International clinical psychopharmacology
  • 2019
TLDR
The purpose of this review is to provide an update on distinguishing features of quazepam with regard to its pharmacology, pharmacokinetics, sleep efficacy and potential adverse effects compared to other agents used for insomnia.
A pharmacodynamic study of quazepam and triazolam
TLDR
Computer analysis of SEM is more sensitive than CRT and CFFT to detect sedative drug effects at a subclinical level and the pharmacodynamic profile of quazepam seems to be characteristic of a “non‐sedative” agent, while triazolam behaves as a ‘sedative' benzodiazepine.
Hypnotics and sedatives
Sleep maintenance insomnia: strengths and weaknesses of current pharmacologic therapies.
  • R. Rosenberg
  • Psychology, Medicine
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
  • 2006
TLDR
New agents that offer relief of sleep maintenance insomnia without residual next day impairment while improving next day function are needed.
Manifestations and management of chronic insomnia in adults.
TLDR
The Sleep in America Poll, conducted by the National Sleep Foundation, revealed that almost 50 percent of people surveyed had complaints of frequent insomnia, but only 6 percent were formally diagnosed.
Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.
TLDR
This guideline is designed to establish clinical practice recommendations for the pharmacologic treatment of chronic insomnia in adults, when such treatment is clinically indicated, and includes drugs that are FDA-approved for the treatment of insomnia, as well as several drugs commonly used to treat insomnia without an FDA indication.
Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults
  • Medicine
  • 2016
s from all retrieved articles, including “pearled” publications, were individually assessed by two TF members to determine whether the publication should be included or excluded from further
...
1
2
...

References

SHOWING 1-10 OF 12 REFERENCES
The Effect of a Single Dose of Quazepam (Sch-16134) on the Sleep of Chronic Insomniacs
TLDR
The results indicate that a single dose of quazepam administered for one night was efficacious when measured both objectively by polysomnographic recording and subjectively by questionnaire with no reported side-effects.
Comparison of the hypnotic activity of triazolam, flurazepam hydrochloride, and placebo
  • A. Sunshine
  • Psychology, Medicine
    Clinical pharmacology and therapeutics
  • 1975
TLDR
Results of the patients’ global evaluation of the medications shows that all of the treatments were rated significantly higher than placebo, with the exception of triazolam, 0.4 mg, which was not significantly different from flurazepam, 15 or 30 mg, or from placebo.
Mebutamate as a hypnotic: Clinical trial and statistical considerations
TLDR
Mebutamate performed well and had little toxicity, and in hypnotic power and global evaluation the mean effect of mebutamate, 600 mg and 300 mg, bracketed that of secobarbital, 150 mg.
Long‐Term Hypnotic Efficacy and Safety of Triazolam and Flurazepam
TLDR
There was no tolerance development on either treatment and there were no deleterious effects attributable to either treatment as measured by the 35-Item Hopkins Symptom Checklist or by physical examinations, laboratory tests, ECGs, and ophthalmologic examinations.
Effects of placebo and flurazepam on sleep patterns in insomniac subjeets
TLDR
There was agreement between the subjectioe estimates of sleep and the electroencephalogram (EEG) data in terms of both improvement in sleep induction and sleep maintenance with flurazepam and in the lack of effects with placebo.
The Effect of a New Benzodiazepine on the Polygraphically Monitored Sleep of Normal Volunteers
TLDR
The subjective quality of sleep was improved by the new benzodiazepine hypnotic, and one subject reported that he felt lethargic the day after the largest dose.
Effect of short -term quazepam treatment on outpatients with insomnia
  • Current Therapeutic Research
  • 1981
benzodiazepines on sleep: flurazepam, diazepam, chlordiazepoxide and R05-4200
  • Clinical
  • 1981
Mebutamate as a hypnotic: .cfinical trial and statistical considerations. Clinical Pharmacology and Therapeutics
  • 1979
...
1
2
...