Evaluation of the Short-Term Treatment of Insomnia in Out-Patients with 15 Milligrams of Quazepam
@article{Mendels1983EvaluationOT, title={Evaluation of the Short-Term Treatment of Insomnia in Out-Patients with 15 Milligrams of Quazepam}, author={Joseph Mendels and Stephen L. Stern}, journal={Journal of International Medical Research}, year={1983}, volume={11}, pages={155 - 161} }
The short-term safety and hypnotic efficacy of 15 mg of quazepam was compared with that of placebo in a double-blind study in sixty out-patients with insomnia. All patients received placebo for 3 consecutive nights to establish a baseline; for the next 5 nights thirty patients received quazepam and thirty received placebo. The results indicated that quazepam was significantly more effective than placebo in terms of quantity and quality of sleep and that quazepam was effective on the first night…
11 Citations
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Preliminary evidence suggests that quazepam 15 to 30 mg is as effective as flurAZepam and triazolam in usual therapeutic doses, and causes minimal rebound insomnia following its withdrawal, unlike rapidly eliminated benzodiazepines such as triazlam.
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Quazepam is a benzodiazepine hypnotic that can be useful in the adjunctive pharmacologic treatment of insomnia and is more effective with short‐term use, and with continued use it maintains its efficacy in contrast to both of these drugs which show rapid development of tolerance.
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Benzodiazepines and zolpidem produced reliable improvements in commonly measured parameters of sleep in patients with chronic insomnia, and presented challenges for developing evidence-based guidelines for the use of hypnotics in the management of chronic insomnia.
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The purpose of this review is to provide an update on distinguishing features of quazepam with regard to its pharmacology, pharmacokinetics, sleep efficacy and potential adverse effects compared to other agents used for insomnia.
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Computer analysis of SEM is more sensitive than CRT and CFFT to detect sedative drug effects at a subclinical level and the pharmacodynamic profile of quazepam seems to be characteristic of a “non‐sedative” agent, while triazolam behaves as a ‘sedative' benzodiazepine.
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New agents that offer relief of sleep maintenance insomnia without residual next day impairment while improving next day function are needed.
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The Sleep in America Poll, conducted by the National Sleep Foundation, revealed that almost 50 percent of people surveyed had complaints of frequent insomnia, but only 6 percent were formally diagnosed.
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This guideline is designed to establish clinical practice recommendations for the pharmacologic treatment of chronic insomnia in adults, when such treatment is clinically indicated, and includes drugs that are FDA-approved for the treatment of insomnia, as well as several drugs commonly used to treat insomnia without an FDA indication.
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