Evaluation of the Role of Interleukin-33 in the Pathogenesis and Grade of the Severity of Atopic Dermatitis

@inproceedings{Metwalli2017EvaluationOT,
  title={Evaluation of the Role of Interleukin-33 in the Pathogenesis and Grade of the Severity of Atopic Dermatitis},
  author={Mohamed I. Metwalli and Fathia M Khattab and Gehad Elsayed and Khater and Naglaa Ali Khalifa},
  year={2017}
}
Membrane-bound expression of ST2 is highest on mast cells, Th2 cells and eosinophils which are critical cells in AD. IL-33 receptor complex is activated when IL-33 binds to ST2 and IL-1RAcP and recruits the adaptor molecule MyD88 and IL-1R-associated kinase IRAK [11]. Activated receptor complex induces activation of signaling proteins, including transcription factor NF-KB and the mitogen-activated protein kinase pathway [12]. 

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