Evaluation of the Radiolabeled Boronic Acid-Based FAP Inhibitor MIP-1232 for Atherosclerotic Plaque Imaging

@article{Meletta2015EvaluationOT,
  title={Evaluation of the Radiolabeled Boronic Acid-Based FAP Inhibitor MIP-1232 for Atherosclerotic Plaque Imaging},
  author={Romana Meletta and Adrienne M{\"u}ller Herde and A. Chiotellis and M. Isa and Z. Ran{\vc}i{\'c} and N. Borel and S. Ametamey and S. Kr{\"a}mer and R. Schibli},
  journal={Molecules},
  year={2015},
  volume={20},
  pages={2081 - 2099}
}
  • Romana Meletta, Adrienne Müller Herde, +6 authors R. Schibli
  • Published 2015
  • Chemistry, Medicine
  • Molecules
  • Research towards the non-invasive imaging of atherosclerotic plaques is of high clinical priority as early recognition of vulnerable plaques may reduce the incidence of cardiovascular events. The fibroblast activation protein alpha (FAP) was recently proposed as inflammation-induced protease involved in the process of plaque vulnerability. In this study, FAP mRNA and protein levels were investigated by quantitative polymerase chain reaction and immunohistochemistry, respectively, in human… CONTINUE READING
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