Evaluation of the Presence of 1,3-Dimethylamylamine in Pelargonium Leaves and Essential Oils by Mass Spectrometric and Chromatographic Methods

  title={Evaluation of the Presence of 1,3-Dimethylamylamine in Pelargonium Leaves and Essential Oils by Mass Spectrometric and Chromatographic Methods},
  author={Ma{\'i}ra Kerpel dos Santos and Gabriela Blauth Walber and Tain{\'a} Kreutz and Krissie Daian Soares and Let{\'i}cia Jacobi Danielli and Kristiane de C{\'a}ssia Mariotti and Mara Rejane Ritter and Glen P. Jackson and Luis Arroyo and Renata Pereira Limberger},
Abstract1,3-Dimethylamylamine (DMAA) is known to be added to dietary supplements from synthetic sources and, presumably, from natural geranium oil. However, the natural occurrence of DMAA in geranium oil (Pelargonium graveolens) has been controversial as published studies report contradicting findings. It is unclear if the difference in detection of DMMA in Pelargonium species is a result of the loss during extraction methods, different detection capabilities of analytical methods or if the… 
2 Citations

Miniaturized Analysis of Methylhexanamine in Urine by Gas Chromatography Applying In Situ Derivatization

The use of stimulants by professional and amateur athletes, as well as in the general population, to enhance their athletic performance represents a human health hazard. Methylhexaneamine (MHA) is a



Analysis of 1,3 dimethylamylamine concentrations in Geraniaceae, geranium oil and dietary supplements.

This study indicates DMAA contained in DS is of a synthetic origin and is not present in the plant species Geranium and Pelargonium; thus the 'natural' origin and use of DMAA as an ingredient inDS is not substantiated.

1,3-Dimethylamylamine (DMAA) in supplements and geranium products: natural or synthetic?

The enantiomeric and diastereomersic ratios of two different known synthetic DMAA compounds, as well as the total concentrations of DMAA and its stereoisomeric ratios in 13 different supplements, were determined by gas chromatography.

Pelargonium oil and methyl hexaneamine (MHA): analytical approaches supporting the absence of MHA in authenticated Pelargonium graveolens plant material and oil.

The data show that none of the authenticated P. graveolens essential oils or plant material, nor any commercial volatile oil of Pelargonium (geranium oil) contain MHA at detectable levels (limit of detection: 10 ppb), suggesting that MHA was of synthetic origin.

Fast Identification of 1,3-Dimethylamylamine Using Direct Analysis in Real Time-QToF-MS.

A fast direct analysis in real time-quadrupole time of flight-MS method was used for identification of DMAA in dietary supplements and to determine if this compound is present in geranium (Pelargonium graveolens) plants or oil.

Identification and Quantification of Dimethylamylamine in Geranium by Liquid Chromatography Tandem Mass Spectrometry

This method was successfully applied to the quantitative determination of 1,3- and 1,4-DMAA in both geranium plant and geranium oil.


In this paper, the chemical constituents of geranium oil, collected from Rong Jiang, Guizhou, were studied by means of capillary gas chromatography-mass spectrometry. Over 40 constituents were

Studies of methylhexaneamine in supplements and geranium oil.

This communication shows that geranium oils do not contain methyl hexaneamine and that products labelled as containing geranium oil but which contain methylhexaneamine can only arise from the addition of synthetic material.