Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at SRI International.

@article{Mitchell1988EvaluationOT,
  title={Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at SRI International.},
  author={Alva D. Mitchell and Colette J. Rudd and William J. Caspary},
  journal={Environmental and molecular mutagenesis},
  year={1988},
  volume={12 Suppl 13},
  pages={37-101}
}
SRI used the L5178Y mouse lymphoma cell forward mutation assay to determine the mutagenic activity of 63 coded chemicals from 16 chemical classes. Replicate experiments were performed to assess the reproducibility of the assay within the laboratory. The evaluations (positive or negative) of the first two repeat experiments with the chemicals were the same for 116 (87%) of 134 tests. Evaluational differences between the first two experiments were fewer in the presence of induced S9 (6 tests… CONTINUE READING
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