• Corpus ID: 3849966

Evaluation of the Interaction of Aluminium Metal with Glutathione in Human Blood Components

@article{Khan2012EvaluationOT,
  title={Evaluation of the Interaction of Aluminium Metal with Glutathione in Human Blood Components},
  author={Haroon Khan and M. Farid Khan and Barkat Ali Khan and Ghulam Razaque and Naheed Haque and Basira Akhter and Bakht Zareen},
  journal={Biomedical Research-tokyo},
  year={2012},
  volume={23},
  pages={0}
}
Aluminium metal has important role in the field of medical sciences, but it has been found in various studies that Aluminium can cause numerous toxic effects. Studies have proven the strong affinity of the metalloelements for the sulfhydryl group (SH), present in reduced glutathione (GSH) and other biological molecules. In this context, the study about the possible interaction of Aluminium metal with glutathione in blood components was of interest, as an indication about the extent of Aluminium… 
No Paper Link Available
10 Citations
Background Citations
2

Figures from this paper

10 Citations

1H NMR characterization of complexation of Glutathione with silver and aluminum metals in aqueous solution

Metallo-elements have both pharmacological and toxic effects on plants, animals and humans. These are considered as a major public health issue worldwide. In particular, heavy metals such as silver…

Studies on fate and toxicity of nanoalumina in male albino rats

The data indicated that rats injected with nanoalumina suffered from the oxidative stresses that were dose and time dependent and Al2O3-NPs released into the biospheres could be potentiating a risk to the environment and causing hazard effects on living organisms, including mammals.

Oxidative stress biomarkers, cholinesterase activity and biotransformation enzymes in the liver of dice snake (Natrix tessellata Laurenti) during pre-hibernation and post-hibernation: A possible correlation with heavy metals in the environment.

Differential biochemical responses to metal/metalloid accumulation in organs of an edible fish (Centropomus parallelus) from Neotropical estuaries.

Investigating the influence of emitted Cadmium from crude oil combustion on glutathione level in workers at Al- Qudis power plant, Baghdad

Al-Qudis power plant was chosen, as one of the power stations of Baghdad, to investigate the effects of Cadmium that emitted from combustion of crude oil in that power plant on the workers'…

The protective role of Epigallocatechin gallate (EGCG) on oxidative stress in normal and treated rats with aluminum oxide nanoparticles

There was a highly significant decreased in GSH concentration, SOD activity and CAT activity but significantly increased in MDA level in blood for rats treated with Al2O3-NPs compared to normal control rats.

ESTIMATION OF ALUMINIUM IN MINERS BLOOD SAMPLES BY USING ICP-AES

The purpose of this work is to the determination of Aluminium in blood samples from Aluminium mines workers by using the ICP-AES technique. Based on this material, some conclusions will be drawn…

Formulation, Characteristic Evaluation, Stress Test and Effectiveness Study of Matrix Metalloproteinase-1 (MMP-1) Expression of Glutathione Loaded Alginate Microspheres and Gel

The results of freeze-dried glutathione-loaded alginate microspheres with surfactant with a HLB value equal to 7 can be utilized as potential glutathion delivery systems.

Investigating the influence of emitted arsenic from crude oil combustion on glutathione level in workers at Al- Qudis power plant, in Baghdad, Iraq

R. B BA AR RK KA AT T A AL LI

References

SHOWING 1-10 OF 19 REFERENCES

Effect of aluminium metal on glutathione (GSH) level in plasma and cytosolic fraction of human blood.

The effect of Aluminum as helping agent for the Glutathione to enhance the antioxidant system of the body or a cause for depletion of reduced GlutATHione is shown.

Effect of lithium metal on the chemical status of glutathione (GSH) present in whole blood (especially in plasma and cytosolic fraction in human blood).

The effect of Lithium on the Thiol/GSH level was discussed in vitro, which in principal may present a model of in vivo reaction.

Lipoic acid increases glutathione production and enhances the effect of mercury in human cell lines.

Glutathione: Systemic Protectant Against Oxidative and Free Radical Damage

Its high electron-donating capacity combined with its high intracellular concentration endows GSH with great reducing power, which is used to regulate a complex thiol-exchange system (—SH —S-S—).

Regulation of hepatic glutathione synthesis: current concepts and controversies

  • Shelly C. Lu
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1999
This work has shown that both transcriptional and post‐transcriptional mechanisms modulate the activity of this critical cellular enzyme, glutathione, in a tightly regulated manner in mammalian cells.

Glutathione: interorgan translocation, turnover, and metabolism.

  • O. GriffithA. Meister
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1979
The present and earlier findings lead to a tentative scheme for the metabolism and translocation of glutathione, gamma-glutamyl amino acids, and related compounds.

Protein-calorie malnutrition: a study of red blood cell and serum enzymes during and after crisis.

  • Z. VerjeeR. Behal
  • Biology
    Clinica chimica acta; international journal of clinical chemistry
  • 1976

Thimerosal induces TH2 responses via influencing cytokine secretion by human dendritic cells

Data suggest that modulation of TH2 responses by mercury and thimerosal, in particular, is through depletion of GSH in DC.

In vitro induction of reactive oxygen species by 2,3,7,8-tetrachlorodibenzo-p-dioxin, endrin, and lindane in rat peritoneal macrophages, and hepatic mitochondria and microsomes.

Tissue sulfhydryl groups.

  • G. Ellman
  • Chemistry
    Archives of biochemistry and biophysics
  • 1959