• Corpus ID: 3849966

Evaluation of the Interaction of Aluminium Metal with Glutathione in Human Blood Components

@article{Khan2012EvaluationOT,
  title={Evaluation of the Interaction of Aluminium Metal with Glutathione in Human Blood Components},
  author={Haroon Khan and M. Farid Khan and Barkat Ali Khan and Ghulam Razaque and Naheed Haque and Basira Akhter and Bakht Zareen},
  journal={Biomedical Research-tokyo},
  year={2012},
  volume={23},
  pages={0}
}
Aluminium metal has important role in the field of medical sciences, but it has been found in various studies that Aluminium can cause numerous toxic effects. Studies have proven the strong affinity of the metalloelements for the sulfhydryl group (SH), present in reduced glutathione (GSH) and other biological molecules. In this context, the study about the possible interaction of Aluminium metal with glutathione in blood components was of interest, as an indication about the extent of Aluminium… 

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References

SHOWING 1-10 OF 19 REFERENCES

Effect of aluminium metal on glutathione (GSH) level in plasma and cytosolic fraction of human blood.

The effect of Aluminum as helping agent for the Glutathione to enhance the antioxidant system of the body or a cause for depletion of reduced GlutATHione is shown.

Effect of lithium metal on the chemical status of glutathione (GSH) present in whole blood (especially in plasma and cytosolic fraction in human blood).

The effect of Lithium on the Thiol/GSH level was discussed in vitro, which in principal may present a model of in vivo reaction.

Glutathione: Systemic Protectant Against Oxidative and Free Radical Damage

Its high electron-donating capacity combined with its high intracellular concentration endows GSH with great reducing power, which is used to regulate a complex thiol-exchange system (—SH —S-S—).

Regulation of hepatic glutathione synthesis: current concepts and controversies

  • Shelly C. Lu
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1999
This work has shown that both transcriptional and post‐transcriptional mechanisms modulate the activity of this critical cellular enzyme, glutathione, in a tightly regulated manner in mammalian cells.

Glutathione: interorgan translocation, turnover, and metabolism.

  • O. GriffithA. Meister
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1979
The present and earlier findings lead to a tentative scheme for the metabolism and translocation of glutathione, gamma-glutamyl amino acids, and related compounds.

Protein-calorie malnutrition: a study of red blood cell and serum enzymes during and after crisis.

  • Z. VerjeeR. Behal
  • Biology
    Clinica chimica acta; international journal of clinical chemistry
  • 1976

Thimerosal induces TH2 responses via influencing cytokine secretion by human dendritic cells

Data suggest that modulation of TH2 responses by mercury and thimerosal, in particular, is through depletion of GSH in DC.

Tissue sulfhydryl groups.

  • G. Ellman
  • Chemistry
    Archives of biochemistry and biophysics
  • 1959