Evaluation of the Influence of Corneal Biomechanical Properties on Intraocular Pressure Measurements Using the Ocular Response Analyzer

  title={Evaluation of the Influence of Corneal Biomechanical Properties on Intraocular Pressure Measurements Using the Ocular Response Analyzer},
  author={Felipe A. Medeiros and Robert N. Weinreb},
  journal={Journal of Glaucoma},
PurposeThe Ocular Response Analyzer (ORA) proposes to measure corneal biomechanical properties in vivo by monitoring and analyzing the corneal behavior when this structure is submitted to a force induced by an air jet. The purpose of this study was to evaluate the relationship between corneal biomechanical properties and corneal-compensated intraocular pressure (IOPCC) measurements as obtained by the ORA and Goldmann applanation tonometry (GAT) measurements. DesignObservational clinical study… 

Intraocular pressure measurements and biomechanical properties of the cornea in eyes after penetrating keratoplasty.

Repeatability of intraocular pressure and corneal biomechanical properties measurements by the ocular response analyser.

ORA measurements show good short-term repeatability in normal volunteers, and appears to be applicable in clinical practice, suggesting corneal biomechanical properties of the Ocular Response Analyser are applicable inclinical practice.

Relationship between novel intraocular pressure measurement from Corvis ST and central corneal thickness and corneal hysteresis

The bIOP measurement from CST is independent from CCT, but dependent on CH and CRF, which is in comparison with IOP measured with Goldmann applanation tonometry and the ocular response analyzer.

[The influence of corneal hysteresis and corneal resistance factor on the measurement of intraocular pressure].

The value that is adjusted by measurement of viscoelastic properties of the cornea, in contrast to GAT and NCT does not depend on central corneal thickness.

Evaluation of Corneal Biomechanical Properties with the Reichert Ocular Response Analyzer

Patients with glaucoma seem to have distinctive corneal biomechanical properties compared to OHT and NL, which may be influenced by many other unknown subparameters.

Reproducibility and clinical relevance of the ocular response analyzer in nonoperated eyes: corneal biomechanical and tonometric implications.

Considering the effect of ORA, corneal biomechanical metrics produces an outcome-significant IOP adjustment in at least one quarter of glaucomatous and normal eyes undergoing noncontact tonometry.

Assessment of corneal biomechanical properties and intraocular pressure with the Ocular Response Analyzer in childhood myopia

Lower CH and CRF were associated with longer AL but not corneal curvature, demonstrating the importance of CH as a determinant of ocular biometry in both the anterior and posterior segments.

Correlation between Corneal Biomechanics and Intraocular Pressure

CCT affect corneal biomechanical properties, the higher CCT the higher were CH and CRF and vice versa, and cornea biomechanics affect IOP more than CCT.

Assessment of the Ocular Response Analyzer as an Instrument for Measurement of Intraocular Pressure and Corneal Biomechanics

The results of this study show the potential of the ORA to provide reliable IOP measurements with weak dependence on the cornea’s stiffness parameters and the considerably reduced reliability in producing stiffness estimates that are unaffected by IOP values.

Analysis of differences in intraocular pressure evaluation performed with contact and non-contact devices

GAT tonometer cannot be used interchangeably with DCT, RT, ORA and CST, and all the IOP measures and the differences between devices were significantly correlated with CCT.



Influence of corneal biomechanical properties on intraocular pressure measurement: Quantitative analysis

Determining in vivo biomechanical properties of the cornea with an ocular response analyzer

  • D. Luce
  • Medicine
    Journal of cataract and refractive surgery
  • 2005

Corneal thickness in ocular hypertension, primary open-angle glaucoma, and normal tension glaucoma.

Patients with NTG have a thinner CCT than do patients with POAG or controls, while overestimation of the IOP in normal subjects who have thick corneas may lead to a misdiagnosis of OHT.


It is concluded that the central corneal thickness is a parameter which should be taken into consideration when evaluating applanation tonometer readings.

The effect of corneal thickness on applanation tonometry.

The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma.

Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS and central corneal thickness was found to be a powerful predictor for the development ofPOAG.

Sources of error with use of Goldmann-type tonometers.