Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride

@article{Vyshtakalyuk2017EvaluationOT,
  title={Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride},
  author={Alexandra B Vyshtakalyuk and Nail Gosmanovich Nazarov and Vladimir V. Zobov and Sayar R. Abdulkhakov and Oksana A Minnekhanova and Vyacheslav E Semenov and I. V. Galyametdinova and Georgy V Cherepnev and Vladimir S. Reznik},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2017},
  volume={162},
  pages={340-342}
}
Hepatoprotective properties of a new pyrimidine derivative — L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, synthesized on the basis Xymedon, were assessed in white rats exposed to CCl4. The compound under study administered prior to exposure to CCl4 reduced the deviation of biochemical parameters from reference values and severity of structural and morphological changes in liver, when compared to the control. Hepatoprotective properties of the studied compound were… CONTINUE READING
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