Evaluation of the Efficacy and Tolerance of a Topical Gel With 4% Quassia Extract in the Treatment of Rosacea

@article{Ferrari2012EvaluationOT,
  title={Evaluation of the Efficacy and Tolerance of a Topical Gel With 4\% Quassia Extract in the Treatment of Rosacea},
  author={Alicia Ferrari and Christian Diehl},
  journal={The Journal of Clinical Pharmacology},
  year={2012},
  volume={52}
}
Background: There are various treatment options available for rosacea, depending on the subtype, but treatment is still generally unsatisfactory. Some studies have reported antiparasitic and anti‐inflammatory properties of Quassia amara. 
Topical Treatment of Rosacea
TLDR
Topical treatment is a cornerstone of rosacea management in all stages of the disease and aims to reduce signs of inflammation, prevent common relapses, and avoid triggers such as skin irritation and ultraviolet (UV)-irradiation. Expand
Novel antibacterial, antifungal and antiparasitic activities of Quassia amara wood extract
TLDR
This is the first time that Quassia amara ethanol wood extract (QWE) is shown to have antiparasitic activity on Trichomonas vaginalis and Demodex spp, an antifungal activity on Malassezia furfur and Candida spp and an antibacterial activity on P. acnes. Expand
The Role of Polyphenols in Rosacea Treatment: A Systematic Review.
TLDR
There is evidence that polyphenols may be beneficial for the treatment of rosacea symptoms and Polyphenols appear to be most effective at reducing facial erythema and papule and pustule counts. Expand
Superiority of Quassia Amara 4% Cream over Metronidazole 0.75% Cream in the Treatment of Rosacea: A Randomized, Double-Blinded Trial
TLDR
The data implicated that QA 4% cream is superior to MTZ 0.75% cream in the management of flushing and telangiectasiae and the activity of both products is similar as regards improvement of erythema and reduction of the number of papules and pustules. Expand
A rosácea e a sua compreensão : etiopatogenia e clínica
Trabalho final de mestrado integrado em Medicina, area cientifica de Dermatologia, apresentado a Faculdade de Medicina da universidade de Coimbra
Rosacea: Diagnosis and management.
TLDR
The pathophysiology of rosacea, its clinical presentation, including the four stages and subtypes of the condition, differential diagnoses, latest treatment strategies, and implications for practice are discussed. Expand
Health Benefits of Quassin from Quassia amara: A Comprehensive Review of their Ethnopharmacological Importance, Pharmacology, Phytochemistry and Analytical Aspects
TLDR
The purpose of this review is to gain an understanding of the Quassin and Quassia amara and to present information and knowledge regarding this phytoconstituent. Expand
Phytochemical and Botanical Therapies for Rosacea: A Systematic Review
TLDR
Several plant extract and phytochemicals effectively improved facial erythema and papule/pustule counts caused by rosacea and further research is critical, as many botanicals have been evaluated in only one study. Expand
New Herbal Biomedicines for the Topical Treatment of Dermatological Disorders
TLDR
This nonsystematic review focuses on herbal drugs that were tested in controlled clinical studies or in scientifically sound preclinical studies and are intended to treat atopic dermatitis, herpes simplex, rosacea and acne vulgaris. Expand
Update on the Management of Rosacea
TLDR
The treatments currently available and opinions regarding emerging and combination therapies for rosacea are described and given. Expand
...
1
2
...

References

SHOWING 1-10 OF 33 REFERENCES
Topical azelaic acid in the treatment of rosacea
TLDR
The results of a single-centre double-blind controlled contralateral split-face study of the effects of 20% azelaic acid cream in patients with rosacea showed both ‘sides’ showed a reduction in papules, pustules and erythema, although the degree of improvement was superior on the azelaing acid-treated sides. Expand
Efficacy and safety of azelaic acid (15%) gel as a new treatment for papulopustular rosacea: results from two vehicle-controlled, randomized phase III studies.
TLDR
The results of these 2 controlled studies demonstrate that AzA gel, used twice daily, is an efficacious, safe, and well-tolerated topical treatment for moderate, papulopustular rosacea. Expand
Evaluation of the analgesic and antiedematogenic activities of Quassia amara bark extract.
TLDR
Although the mechanisms are uncertain, the results demonstrated that these effects are apparently related to sedative and muscle relaxant or psychomimetic activities of the HEX extract of the plant. Expand
Evaluation of Topical Metronidazole Gel in Acne Rosacea
TLDR
Topical metronidazole gel, as specifically formulated, is safe and effective in reducing the symptomatology of acne rosacea and indicates a high safety profile for this therapeutic agent. Expand
[Prophylaxis and treatment of pediculosis with Quassia amarga].
  • M. Ninci
  • Medicine
  • Revista de la Facultad de Ciencias Medicas
  • 1991
TLDR
The prophylactic and therapeutic action of the Quassia Amarga in the human pediculosis is confirmed and a noticeable reduction in expenses to eradicate permanently this form of parasitation at an official as well as at a community level is of importance. Expand
Prophylaxis and treatment of pediculosis with Quassia amarga
TLDR
The prophylactic and therapeutic action of the Quassia Amarga in the human pediculosis is confirmed and a noticeable reduction in expenses to eradicate permanently this form of parasitation at an official as well as at a community level is of importance. Expand
The CLEAR trial: results of a large community-based study of metronidazole gel in rosacea.
TLDR
The findings of this study expand the collected data on the efficacy and safety of metronidazole topical gel 0.75% beyond that demonstrated in controlled clinical trials and confirm the utility of this therapy in the community setting. Expand
A double-blind, multicenter clinical trial comparing efficacy of once-daily metronidazole 1 percent cream to vehicle in patients with rosacea.
TLDR
The efficacy and safety of a new formulation of metronidazole 1 percent cream applied once daily was compared to vehicle cream in a double-blind, randomized, parallel group, ten-week clinical study and it was significantly better than vehicle in reducing the lesions of rosacea and improving erythema. Expand
The efficacy of metronidazole 1% cream once daily compared with metronidazole 1% cream twice daily and their vehicles in rosacea: a double-blind clinical trial.
TLDR
The protocol was approved by an institutional review board, the patients gave a written informed consent, and an ANOVA model was used for statistical analysis. Expand
Double-blind comparison of azelaic acid 20% cream and its vehicle in treatment of papulo-pustular rosacea.
TLDR
Azelaic acid 20% cream is effective and well tolerated in the treatment of papulo-pustular rosacea and results in significantly greater mean reductions in total inflammatory lesions than did vehicle. Expand
...
1
2
3
4
...