Evaluation of the Effectiveness of Imiquimod and 5-Fluorouracil for the Treatment of Actinic Keratosis: Critical Review and Meta-analysis of Efficacy Studies

@article{Gupta2005EvaluationOT,
  title={Evaluation of the Effectiveness of Imiquimod and 5-Fluorouracil for the Treatment of Actinic Keratosis: Critical Review and Meta-analysis of Efficacy Studies},
  author={Aditya K. Gupta and Valerie Davey and Heather Mcphail},
  journal={Journal of Cutaneous Medicine and Surgery},
  year={2005},
  volume={9},
  pages={209-214}
}
Background:Actinic keratosis lesions occur frequently on sun-exposed skin of Caucasians. They become more prevalent with advancing age and are important in identifying the risk factor of those people possibly predisposed to invasive squamous cell carcinoma. Topical therapies are useful alternatives to cryotherapy for treating diffuse actinic damage and a number of preparations have been developed for treating actinic keratosis.Objectives:A cumulative meta-analysis was performed to determine the… 
Case-based experience in the use of 5-fluorouracil cream 0.5% as monotherapy and in conjunction with glycolic acid peels for the treatment of actinic keratosis
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TLDR
The cases presented here demonstrate the use of topical 5-fluorouracil cream 0.5% as monotherapy and in conjunction with glycolic acid peels to treat facial actinic keratoses in two patients with extensive histories of prior actic keratosis and skin cancer.
Comparison of topical 5-fluorouracil formulations in actinic keratosis treatment
TLDR
Clinical trials examining the efficacy of 5-FU cream formulations (0.5% and 5%) in treating multiple AKs of the face and scalp are evaluated to enable dermatologists to appropriately balance the risks and benefits of each respective treatment to provide optimal solutions to patients with multipleAKs.
Imiquimod 3.75% cream (Zyclara) for the treatment of actinic keratoses
TLDR
Imiquimod 3.75% is an interesting, safe and well-tolerated treatment option for actinic keratoses of the face or balding scalp especially in respect of compliance, as it is indicated for daily use for a shorter time period and approved for use on larger areas compared with imiquIMod 5%.
Topical 5-Fluorouracil for the Treatment of Periocular Actinic Keratosis and Low-Grade Squamous Malignancy
TLDR
Topical 5-FU may be useful in the treatment of periocular actinic keratoses and squamous cell carcinoma in situ and the authors experience with lesions involving the eyelids, including the eyelid margin is described.
Fluorouracil Formulations for the Treatment of Actinic Keratosis
TLDR
An overview of the literature focussing on clinical trials and the efficacy of the following fluorouracil formulations currently approved by the US FDA: 0.5% cream, 2% solution, and 5% cream and solution indicates each are effective and safe in the management of actinic keratosis.
Safety, efficacy, and patient acceptability of imiquimod for topical treatment of actinic keratoses
TLDR
An indepth review of the literature, and clinical evidence for its inclusion in the arsenal of treatment options for patients with actinic keratoses is provided.
A Network Meta-Analysis of the Relative Efficacy of Treatments for Actinic Keratosis of the Face or Scalp in Europe
TLDR
This network meta-analysis showed that BF-200 ALA, using narrow-band lights, was the most efficacious treatment for mild to moderate AK on the face and scalp.
Long-term Efficacy of Topical Fluorouracil Cream, 5%, for Treating Actinic Keratosis: A Randomized Clinical Trial.
TLDR
The results indicate that a single course of fluorouracil cream, 5%, effectively reduces AK counts and the need for spot treatments for longer than 2 years.
Effectiveness of 5‐fluorouracil treatment for actinic keratosis – a systematic review of randomized controlled trials
TLDR
Despite the widespread use of 5-FU to treat AK, the evidence supporting its use has not been reviewed systematically or appraised critically, unlike that for imiquimod, and to identify areas in which further research is needed.
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TLDR
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TLDR
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TLDR
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