Evaluation of the C-terminal C5a effector site with short synthetic C5a analog peptides.

@article{Khl1993EvaluationOT,
  title={Evaluation of the C-terminal C5a effector site with short synthetic C5a analog peptides.},
  author={J{\"u}rgen K{\"o}hl and B L{\"u}bbers and Andreas Klos and Wilfried Bautsch and Monika Casaretto},
  journal={European journal of immunology},
  year={1993},
  volume={23 3},
  pages={
          646-52
        }
}
Biological activities have been determined for a series of 18 peptides based on the C-terminal sequence of human or rat C5a. Lysosomal enzyme release was tested in two cell types, the promyelotic leukemia cell line U937 and polymorphonuclear leukocytes. In addition, an ATP-release assay with guinea pig platelets was performed. It was demonstrated that the C-terminal octapeptide 67-74 of human C5a represents the minimal sequence required to induce a measurable biological signal in all assays… CONTINUE READING