Evaluation of the Biological Properties and the Enzymatic Stability of Glycosylated Luteinizing Hormone-Releasing Hormone Analogs

Abstract

The enzymatic stability, antitumor activity, and gonadotropin stimulatory effects of glycosylated luteinizing hormone-releasing hormone (LHRH) analogs were investigated in this study. Conjugation of carbohydrate units, including lactose (Lac), glucose (GS), and galactose (Gal) to LHRH peptide protected the peptide from proteolytic degradation and increased… (More)
DOI: 10.1208/s12248-015-9769-x

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@article{Moradi2015EvaluationOT, title={Evaluation of the Biological Properties and the Enzymatic Stability of Glycosylated Luteinizing Hormone-Releasing Hormone Analogs}, author={Shayli Varasteh Moradi and Pegah Varamini and Istvan Toth}, journal={The AAPS Journal}, year={2015}, volume={17}, pages={1135-1143} }