Evaluation of the Antigenotoxic Effects of the Royal Sun Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) in Human Lymphocytes Treated with Thymol in the Comet Assay.

@article{Radakovi2015EvaluationOT,
  title={Evaluation of the Antigenotoxic Effects of the Royal Sun Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) in Human Lymphocytes Treated with Thymol in the Comet Assay.},
  author={M. Radakovi{\'c} and N. Djeli{\'c} and J. Stevanovi{\'c} and M. Sokovi{\'c} and D. Radovi{\'c} and L. V. van Griensven and Z. Stanimirovi{\'c}},
  journal={International journal of medicinal mushrooms},
  year={2015},
  volume={17 4},
  pages={
          321-30
        }
}
The aim of this investigation was to evaluate the possible protective activity of Agaricus brasiliensis (=A. blazei sensu Murrill) ethanol extract against thymol-induced DNA damage in human lymphocytes. Before we studied the possible interaction of thymol and A. brasiliensis extract, each component was tested in the comet assay. Thymol significantly increased DNA damage in human lymphocytes at higher concentrations (20, 50, 100, 150, and 200 µg/mL), whereas no genotoxic effect of A… Expand
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