Evaluation of the Antibacterial Effects of Flavonoid Combination from the Leaves of Dracontomelon dao by Microcalorimetry and the Quadratic Rotary Combination Design

  title={Evaluation of the Antibacterial Effects of Flavonoid Combination from the Leaves of Dracontomelon dao by Microcalorimetry and the Quadratic Rotary Combination Design},
  author={Yang Li and Hou-lin Xia and Mingquan Wu and Jiabo Wang and Xiaohua Lu and Shizhang Wei and Kun Li and Lifu Wang and Rui-Lin Wang and Pan Zhao and Yanling Zhao and Xiaohe Xiao},
  journal={Frontiers in Pharmacology},
Skin infectious disease is a common public health problem due to the emergence of drug-resistant bacteria caused by the antibiotic misuse. Dracontomelon dao (Blanco) Merr. et Rolfe, a traditional Chinese medicine, has been used for the treatment of various skin infectious diseases over 1000 of years. Previous reports have demonstrated that the leaves of D. dao present favorable antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtitles… 
Antibacterial evaluation of plants extracts against ampicillin-resistant Escherichia coli (E. coli) by microcalorimetry and principal component analysis
In conclusion, sample S6 from the EtOAc fraction of D. dao leaves could be used as a potential antimicrobial resource in the treatment of infectious diseases and provides an insight into the effect of traditional Chinese medicine on drug-resistant bacteria.
D. dao stem bark extracts are potential to develop as antibacterial agent especially against MRSA and E.coli MDR bacteria and in TLC results, colorless bands found to be secondary metabolites with antibacterial activity.
The Antimicrobial Activities of Silver Nanoparticles from Aqueous Extract of Grape Seeds against Pathogenic Bacteria and Fungi
The results showed significant antimicrobial activities of GSE-AgNPs against all tested species, unlike GSE, which had weaker and limited effects.
Regulatory Roles of Flavonoids on Inflammasome Activation during Inflammatory Responses
  • Young-Su Yi
  • Chemistry, Medicine
    Molecular nutrition & food research
  • 2018
Understanding the regulatory effects of flavonoids on inflammasome activation will increase the knowledge of flav onoid-mediated anti-inflammatory activity and provide new insights into the development of Flavonoid preparations to prevent and treat human inflammatory diseases.
A rapid and efficient extraction method based on industrial MCM-41-miniaturized matrix solid-phase dispersion extraction with response surface methodology for simultaneous quantification of six flavonoids in Pollen typhae by ultra-high-performance liquid chromatography.
It was proven that the developed industrial MCM-41-miniaturized matrix solid-phase dispersion extraction coupled with simple ultra-high performance liquid chromatography method could be a rapid and efficient tool for extraction and determination of flavonoids in natural products.
Cell Temperature Measurement for Biometabolism Monitoring.
The latest advances in temperature sensors for biological detection and their related applications in metabolic research are introduced.


Antibacterial evaluation of flavonoid compounds against E. coli by microcalorimetry and chemometrics
This study provides a valuable method for searching for novel antibacterial agents using microcalorimetry with chemometrics for evaluating the influence of two flavonoid compounds on Escherichia coli.
Antibacterial activity and acute toxicity effect of flavonoids extracted from Mentha longifolia.
2 Abstract: The methanolic and ethanolic extracts of Mentha longifolia were tested for their antimicrobial activity against some clinical bacteria. Then, a phytochemical screening was realized for
Anti-bacterial effect of four extracts from leaves of Dracontomelon dao on Escherichia coli growth using microcalorimetry coupled with principal component analysis
The anti-Escherichia coli activities of four extracts in leaves of Dracontomelon dao, a traditional folk herb in China were investigated and compared by microcalorimetry. The four extracts are PE
Microcalorimetry coupled with principal component analysis for investigating the anti-Staphylococcus aureus effects of different extracted fractions from Dracontomelon dao
With the prevalence resistance of Staphylococcus aureus to antibacterial agents, developing novel antibacterial agents is urgent. Recently, plant extracts have got more focus. In this study, the
Screening for novel antibacterial agents based on the activities of compounds on metabolism of Escherichia coli: a microcalorimetric study.
The microcalorimetric method was used to measure the metabolic curves of E. coli growth affected by chenodeoxycholic acid (CDCA) and UDCA and showed stronger activities on non-multiplying metabolism than on multiplying metabolism of the bacteria.
Microcalorimetry and turbidimetry to investigate the anti-bacterial activities of five fractions from the leaves of Dracontomelon dao on P. aeruginosa
As a healthcare-associated pathogen with the resistance to anti-bacterial agent, P. aeruginosa has caused prevalent public burden and should not be ignored. Facing the realistic situation, developing
Study on the Chemical Constituents of Essential Oil from the Skins of Stem of Dracontomelon dao (Blanco) Merr.et Rolfe
Objective To analyze the chemical constituents of essential oil from the skins of stem of Dracontomelon dao(Blanco)Merr.et Rolfe.MethodsThe essential oil was extracted from the skins of stem of
Evaluation of the antimicrobial mode of berberine by LC/ESI-MS combined with principal component analysis.
In this investigation, metabolic profiles of Staphylococcus aureus treated by berberine and nine antibacterial substances with known modes of action were acquired by HPLC/ESI-MS and the possible antibacterial mode of berberines was evaluated.
Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents.
A series of luteolin derivatives 2-20 were prepared and most of them displayed significant activity against the tested strains, and 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-hydroxy-7-(2-(3-morpholinopropylamino)ethoxy)-4H-chromen-4-one showed the most favorable antibacterial activity in vitro.
Spectrum-effect relationships between UPLC fingerprints and bioactivities of crude secondary roots of Aconitum carmichaelii Debeaux (Fuzi) and its three processed products on mitochondrial growth coupled with canonical correlation analysis.
A general model of combination of UPLC and microcalorimetry is provided to study the spectrum-effect relationships of Fuzi and its processed products which can offer some references for detecting principal components of traditional Chinese medicine on bioactivity to mitochondrial growth.