Evaluation of the Anti‐Diabetic Activity of Polysaccharide from Cordyceps cicadae in Experimental Diabetic Rats

@article{Zhang2018EvaluationOT,
  title={Evaluation of the Anti‐Diabetic Activity of Polysaccharide from Cordyceps cicadae in Experimental Diabetic Rats},
  author={Qianping Zhang and Opeyemi Joshua Olatunji and Hongxia Chen and Adesola Julius Tola and Omolara O. Oluwaniyi},
  journal={Chemistry \& Biodiversity},
  year={2018},
  volume={15}
}
Cordyceps cicadae is a medicinal fungus used in treating night sweat, childhood convulsions, vision improvement and pain. This study was designed to evaluate the anti‐diabetic activity of the crude polysaccharide (SHF) from the mycelium and body portion of C. cicadae. Diabetes mellitus was induced in the rat with a single intravenous injection of alloxan monohydrate (150 mg/kg). In other to evaluate the anti‐diabetic effects of C. cicadae polysaccharide in alloxan‐induced diabetic rats, the… 
Antidiabetic and Nephroprotective Effects of Polysaccharide Extract from the Seaweed Caulerpa racemosa in High Fructose-Streptozotocin Induced Diabetic Nephropathy
TLDR
PCR displayed antidiabetic and nephroprotective effects against DN by impeding oxidative stress and inflammation, and has potentials as a food supplement for alleviating renal dysfunction caused by diabetes.
Glucose-lowering and hypolipidemic activities of polysaccharides from Cordyceps taii in streptozotocin-induced diabetic mice
TLDR
The anti-diabetes effect of CTP is closely associated with immunoregulation and anti-inflammation, and CTP may be considered as a therapeutic drug or functional food for DM intervention.
Lowering the Intraocular Pressure in Rats and Rabbits by Cordyceps cicadae Extract and Its Active Compounds
TLDR
Data showed that CCME could significantly (60.5%) reduce the IOP induced by microbead occlusion after 56 days of oral administration, and the apoptosis of retinal ganglion cells in rats decreased by 77.2%.
N6 -(2-hydroxyethyl)-adenosine from Cordyceps cicadae protects against diabetic kidney disease via alleviation of oxidative stress and inflammation.
TLDR
HEA stimulated the antioxidant enzymes' activities in the kidney tissues as well as reduced pro-inflammatory mediators, indicating its antidiabetic and renoprotective effects in diabetic models.
Polysaccharides from Spores of Cordyceps cicadae Protect against Cyclophosphamide-Induced Immunosuppression and Oxidative Stress in Mice
TLDR
Results indicate that CCSP-2 might be exploited as a promising natural immunomodulator in cyclophosphamide-induced immunosuppressed mice through significantly increasing spleen and thymus indices.
Alleviation of Liver Dysfunction, Oxidative Stress, and Inflammation Underlines the Protective Effects of Polysaccharides from Cordyceps cicadae on High Sugar/High Fat Diet‐Induced Metabolic Syndrome in Rats
TLDR
The results suggested that the polysaccharides from C. cicadae showed protective effects against HF/HFD induced metabolic disturbances and may be considered as a dietary supplement for treating obesity.
Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials
TLDR
This review collects and analyzes state-of-the-art about the properties of Cordyceps species along with ethnopharmacological properties, application in food, chemical compounds, extraction of bioactive compounds, and various pharmacological properties with a special focus on the stimulatory properties of immunity.
DMSO_A_302748 2121..2131
TLDR
PCR displayed antidiabetic and nephroprotective effects against DN by impeding oxidative stress and inflammation, and has potentials as a food supplement for alleviating renal dysfunction caused by diabetes.
Mechanism of Cordyceps Cicadae in Treating Diabetic Nephropathy Based on Network Pharmacology and Molecular Docking Analysis
TLDR
Active ingredients of cordyceps cicadae such as myriocin may act on DN through different targets such as AKT1, MAPK8, and TP53 and other targets, which can help to develop innovative drugs for effective treatment of DN.
...
...

References

SHOWING 1-10 OF 41 REFERENCES
Antihyperglycemic and antihyperlipidemic activities of methanol:water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats.
  • R. KasettiM. Rajasekhar C. A. Rao
  • Medicine, Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2010
Evaluation of In Vitro α‐Amylase and α‐Glucosidase Inhibitory Potentials of 14 Medicinal Plants Constituted in Thai Folk Antidiabetic Formularies
TLDR
Chemical investigation of the active extract of V. glabrata indicated that pentacyclic triterpenes were the major compounds responsible for the activity, suggesting the potential use of the plant as an alternative natural source for the treatment of diabetes mellitus.
Optimized extraction, composition, antioxidant and antimicrobial activities of exo and intracellular polysaccharides from submerged culture of Cordyceps cicadae
TLDR
EPS and IPS production from submerged culture of C. cicadae with significant antioxidant and antibacterial potential can be enhanced with the combination of several factors which can be used for large scale industrial fermentation of the organism.
Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats
TLDR
Taurine supplementation in regular diet could, therefore, be beneficial to regulate diabetes-associated renal complications and protect renal tissue from alloxan-induced apoptosis.
[Polysaccharides in fungi. XXV. Biological activities of two galactomannans from the insect-body portion of Chán hua (fungus: Cordyceps cicadae)].
TLDR
CI-P having low affinity for concanavalin A (Con A) exhibited potent carbon-clearance activity in mouse, although both polysaccharides had little antitumor activity against sarcoma 180 in mice.
The mechanisms of alloxan- and streptozotocin-induced diabetes
TLDR
The targeting of mitochondrial DNA, thereby impairing the signalling function of beta cell mitochondrial metabolism, also explains how streptozotocin is able to inhibit glucose-induced insulin secretion, causing a state of insulin-dependent ‘alloxan diabetes’.
Polysaccharides purified from Cordyceps cicadae protects PC12 cells against glutamate-induced oxidative damage.
...
...