Evaluation of the Abbott TDx analyzer.

  title={Evaluation of the Abbott TDx analyzer.},
  author={C. W. Lee and H. M. Lee},
  journal={Journal of analytical toxicology},
  volume={13 1},
Part I. The Analysis of Opiates in Blood. The Abbott TDx analyzer, which is marketed for the analysis of drugs in urine or serum, was applied to the detection and quantitation of total opiates in whole blood. The analysis was sensitive with a detection limit of about 30 ng/mL. The coefficient of variation in the determination was within 12% for the linear working range of 0-1000 ng/mL. The greatest merits of the method are speed and the small sample size. An analysis can be completed within 15… Expand
Direct semiquantitative screening of drugs of abuse in serum and whole blood by means of CEDIA DAU urine immunoassays.
Serum screening for amphetamines is not sensitive enough in the unchanged urine mode, and will require some adaptation to a serum mode (probably a higher sample volume [BM/Hitachi 911] combined with protein precipitation of the sample). Expand
The determination of drugs of abuse in whole blood by means of FPIA and EMIT-dau immunoassays--a comparative study.
Six groups of common drugs of abuse were determined in whole blood after acetone precipitation, using enzyme multiplied immunoassay (EMIT dau) and fluorescence polarisation immunoASSay (FPIA--Abbott TDx and ADx) methods, which allowed the determination of all above mentioned class of drugs but amphetamine. Expand
Abbott propoxyphene assay: evaluation and comparison of TDx FPIA and GC/MS methods.
This study evaluated the capability of the Abbott TDx assay to test for propoxyphene in urine and various biological samples, including tissues obtained from three fatal overdoses, by comparison toExpand
Preliminary evaluation of the Abbott TDx for screening of D-methamphetamine in whole blood specimens.
The Abbott TDx Urine Amphetamine/Methamphetamine II fluorescence polarization immunoassay technique was applied and found reliable for the screening of hemolyzed whole blood and compared to RIA and GC/MS assays for the methamphetamine controls and for eight positive case specimens. Expand
Direct Detection of Drugs of Abuse in Whole Hemolysed Postmortem Blood and Qualitative Measurement in EDTA - Plasma using the CEDIA DAU Urine Assays
The direct and simple detection of a broad spectrum of drugs in whole hemolysed postmortem blood (Part A) and the possibility of qualitative measurement in serum and whole blood using the clonedExpand
Comparative studies on the detection of benzodiazepines in serum by means of immunoassays (FPIA).
The direct ADx benzodiazepine serum assay has clear advantages over the acetone precipitation method, especially with regard to therapeutic concentrations and for the detection of the highly potent and low-dose Benzodiazepines flunitrazepam and triazolam. Expand
Evaluation of a method for simultaneous quantification of codeine, dihydrocodeine, morphine, and 6-monoacetylmorphine in serum, blood, and postmortem blood
SummaryA solid-phase extraction and gas chromatographic-mass spectrometric method for the simultaneous determination of codeine, dihydrocodeine, morphine, and 6-monoacetylmorphine in serum, blood orExpand
Comparison Between the Abbott TDx Analyzer and Gas Chromatography/Mass Spectrometry in a Fatality Involving Cocaine
A comparison of the results obtained with the Abbott TDx immunofluorescence analyzer and those of gas chromatography coupled to mass spectrometry in a fatal case involving pure cocaine injection is presented. Expand
The screening for common drugs of abuse in whole blood by means of EMIT-ETS and FPIA-ADx urine immunoassays
The comparison of results obtained with ETS and ADx after acetone precipitation showed that ETS assay is slightly more sensitive but AD is slightly less reproducible but both assays may be used for blood examination with similar cut-off values. Expand
Revue générale Préparation d'échantillons pour analyses en immunochimie Sample preparation for immunoassay analysis in toxicology
Introduction: Despite the breakthrough of chromatographic techniques coupled to mass spectrometry, immunoanalysis is still a key component of the various techniques used in clinical or forensicExpand


Fluorescence polarization immunoassay for the determination of therapeutic drug levels in human plasma.
  • M. Jolley
  • Chemistry, Medicine
  • Journal of analytical toxicology
  • 1981
Assays for a variety of therapeutic drugs including gentamicin, theophylline, phenytoin, and phenobarbital have been developed and shown to correlate well with a number of reference method. Expand
Antemortem conversion of codeine to morphine in man.
Evidence was developed that codeine was metabolized partially into morphine in the antemortem stage, and controlled-in-vitro studies showed that no codeine demethylation occurred in postmortem tissues during cold storage for a period as long as 30 days. Expand