Evaluation of testicular toxicology of doxorubicin based on microarray analysis of testicular specific gene expression.

@article{Takahashi2011EvaluationOT,
  title={Evaluation of testicular toxicology of doxorubicin based on microarray analysis of testicular specific gene expression.},
  author={Hikari Takahashi and Hitoshi Tainaka and Masakazu Umezawa and Kazuki Takeda and Hiromitsu Tanaka and Yoshitake Nishimune and Shigeru Oshio},
  journal={The Journal of toxicological sciences},
  year={2011},
  volume={36 5},
  pages={559-67}
}
Testicular toxicity of chemical substances has been generally assessed by sperm properties and histology. However, the methods can provide only a few information of the mechanism of the toxicity. The aim of this study is to show a method that can evaluate an overview of testicular toxic mechanisms using a tissue-specific microarray and classification of genes using Medical Subject Headings (MeSH). Male ICR mice (6 weeks old) were treated with doxorubicin hydrochloride (0, 0.1, 0.3 mg/kg/time… CONTINUE READING