Evaluation of testicular toxicity in safety evaluation studies: the appropriate use of spermatogenic staging.

@article{Creasy1997EvaluationOT,
  title={Evaluation of testicular toxicity in safety evaluation studies: the appropriate use of spermatogenic staging.},
  author={Dianne M Creasy},
  journal={Toxicologic pathology},
  year={1997},
  volume={25 2},
  pages={119-31}
}
Toxicology of the male reproductive system has received increased interest in recent years partly fuelled by the growing reports of falling sperm counts and rising reproductive disorders in the human population. Recently revised regulatory guidelines for the safety assessment of pharmaceuticals and chemicals on reproduction and fertility have emphasized the importance of detailed histopathological examination of the testes as a sensitive method for detecting disturbances in spermatogenesis… CONTINUE READING

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