Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments

@inproceedings{Bullard2009EvaluationOS,
  title={Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments},
  author={James H. Bullard and Elizabeth Purdom and Kasper D. Hansen and Sandrine Dudoit},
  booktitle={BMC Bioinformatics},
  year={2009}
}
High-throughput sequencing technologies, such as the Illumina Genome Analyzer, are powerful new tools for investigating a wide range of biological and medical questions. Statistical and computational methods are key for drawing meaningful and accurate conclusions from the massive and complex datasets generated by the sequencers. We provide a detailed evaluation of statistical methods for normalization and differential expression (DE) analysis of Illumina transcriptome sequencing (mRNA-Seq) data… CONTINUE READING
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