Evaluation of single-drug versus multiple-drug chemotherapy in the treatment of advanced breast cancer.

Abstract

Fifty-one postmenopausal patients with advanced breast cancer were randomized to receive either cyclophosphamide given continuously or cyclophosphamide given continuously with methotrexate, 5-fluorouracil, vincristine, and prednisone given intermittently. The results with the multiple-drug therapy were significantly better than with the single-drug therapy, both with regard to percentage (63% versus 25%) and median duration (400 versus 210 days) of objective response. Toxicity was moderately increased with the combination as compared to the single-drug treatment.

Statistics

0100200'79'82'86'90'94'98'02'06'10'14
Citations per Year

330 Citations

Semantic Scholar estimates that this publication has 330 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Mouridsen1977EvaluationOS, title={Evaluation of single-drug versus multiple-drug chemotherapy in the treatment of advanced breast cancer.}, author={Henning T. Mouridsen and Torben Palshof and Magdalena Brahm and Iben Rahbek}, journal={Cancer treatment reports}, year={1977}, volume={61 1}, pages={47-50} }