Evaluation of simple and complex sensorimotor behaviours in rats with a partial lesion of the dopaminergic nigrostriatal system.

@article{Barnoud2000EvaluationOS,
  title={Evaluation of simple and complex sensorimotor behaviours in rats with a partial lesion of the dopaminergic nigrostriatal system.},
  author={P Barn{\'e}oud and E Descombris and N Aubin and Djoher Nora Abrous},
  journal={The European journal of neuroscience},
  year={2000},
  volume={12 1},
  pages={322-36}
}
We have examined the behavioural consequences of a partial unilateral dopaminergic denervation of the rat striatum. This partial lesion was obtained by an intrastriatal 6-hydroxy-dopamine injection (6-OHDA, 20 or 10 microgram divided between two injection sites) and was compared with a unilateral complete lesion resulting from an injection of 6-OHDA (2 x 6 microgram) into the medial forebrain bundle. Quantification of striatal dopamine (DA) and its metabolites, and the immunohistochemical… CONTINUE READING

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