Evaluation of sigma (σ) receptors in the antidepressant-like effects of ketamine in vitro and in vivo

@article{Robson2012EvaluationOS,
  title={Evaluation of sigma ($\sigma$) receptors in the antidepressant-like effects of ketamine in vitro and in vivo},
  author={Matthew J Robson and Meenal Elliott and Michael J. Seminerio and Rae R. Matsumoto},
  journal={European Neuropsychopharmacology},
  year={2012},
  volume={22},
  pages={308-317}
}
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TLDR
A modulation of serotonergic neurotransmission by some sigma receptors is suggested and a potential mechanism for the ‘antidepressant effects’ reported is provided and evidence is provided toward sigma1 ligands as potential antidepressants with a rapid onset of action.
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TLDR
The present study indicates that a clinically relevant concentration of ketamine interacts with μ2 opioid receptors, however, no agonist activity was observed.
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