Evaluation of sigma (σ) receptors in the antidepressant-like effects of ketamine in vitro and in vivo

@article{Robson2012EvaluationOS,
  title={Evaluation of sigma ($\sigma$) receptors in the antidepressant-like effects of ketamine in vitro and in vivo},
  author={Matthew James Robson and Meenal Elliott and Michael J. Seminerio and Rae R. Matsumoto},
  journal={European Neuropsychopharmacology},
  year={2012},
  volume={22},
  pages={308-317}
}
Ketamine is an NMDA antagonist and dissociative anesthetic that has been shown to display rapid acting and prolonged antidepressant activity in small-scale human clinical trials. Ketamine also binds to σ receptors, which are believed to be protein targets for a potential new class of antidepressant medications. The purpose of this study was to determine the involvement of σ receptors in the antidepressant-like actions of ketamine. Competition binding assays were performed to assess the affinity… Expand
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