Evaluation of serum deoxythymidine kinase as a marker in multiple myeloma

@article{Simonsson1985EvaluationOS,
  title={Evaluation of serum deoxythymidine kinase as a marker in multiple myeloma},
  author={Bengt Simonsson and C K{\"a}llander and Gunilla Brenning and Andreas Killander and Anders {\AA}hre and J. Simon Gronowitz},
  journal={British Journal of Haematology},
  year={1985},
  volume={61}
}
Summary. A recently developed deoxythymidine kinase assay utilizing 125I‐iododeoxyuridine as substrate was used in an investigation of sera from 122 untreated patients with multiple myeloma. Most patients had slightly elevated or normal serum deoxythymidine kinase activity (S‐TK), although in some patients values increased by more than forty‐fold were found. S‐TK correlated with the haemoglobin level but did not correlate with sex, age, erythrocyte sedimentation rate, nor with the serum… 

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References

SHOWING 1-10 OF 18 REFERENCES

Serum deoxythymidine kinase gives prognostic information in chronic lymphocytic leukemia

TLDR
It is concluded that S‐TK could be used as a prognostic marker for the individual CLL patient and seems to be useful for longitudinal follow‐up studies of disease status, both in indolent disease and in progressive disease during treatment.

The use of serum deoxythymidine kinase as a prognostic marker, and in the monitoring of patients with non-Hodgkin's lymphoma.

TLDR
It is concluded that s-dTk could be used both as a prognostic marker and to monitor the effect of therapy in NHL patients.

Application of an in vitro assay for serum thymidine kinase: Results on viral disease and malignancies in humans

TLDR
The TK activity in sera from patients with both mononucleosis and tumor disease was characterized by electrophoresis and by its ability to utilize cytidine triphosphate as the phosphate donor, and showed that the serum TK has the same properties as the human cytosolar TK1, except in connection with varicella.

Serum thymidine kinase in acute leukaemia.

TLDR
The development of a TK assay optimized for TK1, utilizing [1251] iododeoxyuridine as substrate, has been found to facilitate the detection of normal TK kinase activity.

Prognostic relevance of thymidine kinase isozymes in adult non-Hodgkin's lymphoma.

TLDR
It is suggested that peripheral blood TK1 isozyme is a useful independent biochemical marker for a subgroup of NHL who respond poorly to current therapy and thus require new therapeutic approaches.

Serum beta 2-microglobulin in myelomatosis: potential value in stratification and monitoring.

TLDR
Analysis of the influence of a rising serum creatinine on the serum beta 2-m indicates that beta 2 -m production is excessive in advanced disease with or without renal failure.

Deoxycytidine and deoxythymidine kinase activities in plasma of mice and patients with neoplastic disease.

In C57BL x DBA/2 F1 (hereafter called BD2F1) mice inoculated with P815 neoplasms and in AKR mice with spontaneously developing leukemia, significant amounts of plasma deoxycytidine and thymidine

Rapid diagnosis of varicella-zoster virus infection by detection of viral deoxythymidine kinase in serum and vesicle fluid

A sensitive enzyme assay utilizing [125I]iododeoxyuridine as the substrate and CTP as the phosphate donor in combination with isozyme-specific antisera was used for direct detection and typing of

Localized and indolent myeloma.

TLDR
Serial assessments of myeloma protein level provided a useful index of changing tumor load and the need for chemotherapy and the delay of chemotherapy until evidence of tumor progression did not affect the long-term outcome of patients with localized or indolent Myeloma.

A new improved clinical staging system for multiple myeloma based on analysis of 123 treated patients.

TLDR
The comparison of the duration of survival between the three groups of staged patients confirmed the high reliability of the present staging system, and bivariate correlation and multivariate regression analyses showed that the survival could be accurately predicted in IgG and pure Bence Jones myeloma patients.