Evaluation of serum bile acid profiles as biomarkers of liver injury in rodents.

@article{Luo2014EvaluationOS,
  title={Evaluation of serum bile acid profiles as biomarkers of liver injury in rodents.},
  author={Lina Luo and Shelli J. Schomaker and Christopher D Houle and Jiri Aubrecht and Jennifer L Colangelo},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2014},
  volume={137 1},
  pages={12-25}
}
Bile acids (BAs) have been studied as potential biomarkers of drug-induced liver injury. However, the relationship between levels of individual BAs and specific forms of liver injury remains to be fully understood. Thus, we set out to evaluate cholic acid (CA), glycocholic acid (GCA), and taurocholic acid (TCA) as potential biomarkers of liver injury in rodent toxicity studies. We have developed a sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS) assay applicable to rat and… CONTINUE READING
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