Evaluation of selectivity in homologous multimodal chromatographic systems using in silico designed antibody fragment libraries.

Abstract

This study describes the in silico design, surface property analyses, production and chromatographic evaluations of a diverse set of antibody Fab fragment variants. Based on previous findings, we hypothesized that the complementarity-determining regions (CDRs) constitute important binding sites for multimodal chromatographic ligands. Given that antibodies… (More)
DOI: 10.1016/j.chroma.2015.11.047

Topics

Cite this paper

@article{Karkov2015EvaluationOS, title={Evaluation of selectivity in homologous multimodal chromatographic systems using in silico designed antibody fragment libraries.}, author={Hanne Sophie Karkov and James K H Woo and Berit Olsen Krogh and Haleh Ahmadian and Steven M. Cramer}, journal={Journal of chromatography. A}, year={2015}, volume={1426}, pages={102-9} }