Evaluation of selected polymorphisms of the Mendelian hypertensive disease genes in the Japanese population.

@article{Sugiyama2001EvaluationOS,
  title={Evaluation of selected polymorphisms of the Mendelian hypertensive disease genes in the Japanese population.},
  author={Takao Sugiyama and Noriyuki Kato and Yuji Ishinaga and Yukio Yamori and Yoshio Yazaki},
  journal={Hypertension research : official journal of the Japanese Society of Hypertension},
  year={2001},
  volume={24 5},
  pages={515-21}
}
It remains to be defined whether molecular variants of the genes underlying Mendelian forms of hypertension play some etiological role in essential hypertension. To pursue this issue, we focused on the following three genes: the epithelial sodium channel (ENaC), 11beta-hydroxysteroid dehydrogenase type 2, and mineralocorticoid receptor genes. Five sequence variations of these genes, which were either previously reported to show significant association with hypertension or identified as "mild… CONTINUE READING

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